Parcellation of motor cortex-associated regions in the human corpus callosum on the basis of Human Connectome Project data
Parcellation of motor cortex-associated regions in the human corpus callosum on the basis of Human Connectome Project data
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DOI：
10.1007/s00429-019-01849-1
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发表时间：
2019-05-01
影响因子：
3.1
通讯作者：
Lotze, Martin
中科院分区：
文献类型：
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作者：
Domin, Martin;Lotze, Martin
胼胝体（corpus callosum，CC）是大脑中最大的白色结构，为两个大脑半球之间的强烈相互作用提供了结构基础。特别是在两个运动皮层的相互作用方面，它显示出分化的躯体位置组织。神经病理学过程通常反映在CC的结构改变中，并且健康大脑的结构的空间精确描述对于进一步区分患者的结构损伤是必不可少的。我们对人类连接组计划的1065个弥散加权数据集进行了CC的细粒度分割。计算初级运动皮层（M1; Brainnetome Atlas）的半球间相应功能分区之间的半球间纤维束描记图，将其转换为共同空间，取平均值并设定阈值，以评估定位、各向异性分数（FA）和平均扩散率（MD）。确定了每个功能M1细分（下肢和上肢、头/脸、舌/喉）的空间上不同的CC区域，并将其用作解剖学掩模。非参数统计的平均FA和MD值显示所有胼胝体区域之间的显着差异。新提出的胼胝体区域允许精确区分M1-M1运动连接和这些束的结构完整性。在一个共同的空间掩蔽区域的可用性将有助于更好地了解患者或健康志愿者的半球间胼胝体连接。
The corpus callosum (CC) is the largest white matter structure of the brain and offers the structural basis for an intense interaction between both cerebral hemispheres. Especially with respect to the interaction of both motor cortices it shows a differentiated somatotopic organization. Neuropathological processes are often reflected in structural alterations of the CC and a spatially precise description of structures for the healthy brain is essential for further differentiation of structural damage in patients. We performed a fine-grained parcellation of the CC on 1065 diffusion-weighted data sets of the Human Connectome Project. Interhemispheric tractograms between interhemispherically corresponding functional subdivisions of the primary motor cortex (M1; Brainnetome Atlas) were calculated, transformed into a common space, averaged and thresholded, to be assessed for localization, fractional anisotropy (FA) and mean diffusivity (MD). Spatially distinct CC regions for each functional M1 subdivision (lower and upper limbs, head/face, tongue/larynx) were identified and will be available as anatomical masks. Non-parametrical statistics for the average FA and MD values showed significant differences between all callosal regions. The newly proposed callosal regions allow for a precise differentiation of M1-M1 motor connectivity and the structural integrity of these tracts. Availability of masked regions in a common space will help to better understand inter-hemispherical callosal connectivity in patients or healthy volunteers.