VARIATIONS IN SMALL AND LARGE VESSEL VOLUMES CAUSED BY CATIONS ADRENALINE AND HISTAMINE
VARIATIONS IN SMALL AND LARGE VESSEL VOLUMES CAUSED BY CATIONS ADRENALINE AND HISTAMINE
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DOI：
10.1113/jphysiol.1967.sp008130
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发表时间：
1967-01-01
影响因子：
5.5
通讯作者：
CHACALOS, EH
中科院分区：
文献类型：
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作者：
CHACALOS, EH
用巴比妥钠麻醉的急性脾切除犬，用[~(131)I]白蛋白、[P_(32)]红细胞和动脉血红细胞同时测定血浆和血细胞体积。这些测量是在对照运行期间和给药血管活性物质之后进行的。利用这些数据和以前推导的公式，可以计算出半径为150[亩]的所有小血管的平均复合半径，小血管和大血管之间的血容量分布，以及其他变量。肾上腺素、CaCl2或加压素使平均复合半径减小，红细胞和血浆净移出小血管体积，大血管体积扩大。组胺、氯化钾和氯化镁的作用相反。肾上腺素似乎导致隔离的红细胞释放到活跃的循环中。CaCl2和Kc1的影响持续了几个小时，而MgCl2的影响则没有。加压素的作用可被组胺逆转，肾上腺素的作用可被脾血浆或Kc1逆转，CaCl2的作用可被氯化镁逆转。有人认为，所观察到的血管作用本质上是直接和间接作用在小血管体积的电容部分的不同组合的结果。
Plasma and blood cell volumes were measured simultaneously with [I131]albumin and [P32]erythrocytes, together with the arterial hematocrits, in acutely splenectomized dogs anesthetized with sodium barbital. These measurements were made during control runs and after the administration of vasoactive substances. With these data and previously derived equations the mean composite radius of all small vessels with a radius < 150 [mu], the distribution of the blood volumes between small and large vessels, and other variables could be calculated. Adrenaline [epinephrine], CaCl2 or vasopressin administration caused a reduction of the mean composite radius, a net shift of erythrocytes and plasma out of the small vessel volume, and an expansion of the large vessel volume. Histamine, KC1 and MgCl2 produced opposite effects. Epinephrine appeared to cause the release of sequestered erythrocytes into the active circulation. The effects of CaCl2 and KC1 persisted for several hours, while those of MgCl2 did not. The effects of vasopressin could be reversed by histamine, those of epinephrine by splenic plasma or KC1, and those of CaCl2 by MgCl2. It was suggested that the observed vaso-actions are essentially the resultants of diverse combinations of direct and indirect actions on the capacitance section of the small vessel volume.