Gender-related differences in heart failure with preserved ejection fraction.
Gender-related differences in heart failure with preserved ejection fraction.
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与性别相关的心力衰竭差异，保留的射血分数。
DOI：
10.1038/s41598-018-19507-7
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发表时间：
2018-01-18
影响因子：
4.6
通讯作者：
Bonderman D
中科院分区：
文献类型：
--
作者：
Duca F;Zotter-Tufaro C;Kammerlander AA;Aschauer S;Binder C;Mascherbauer J;Bonderman D
射血分数保留性心力衰竭（HFpEF）影响女性多于男性，表明性别在疾病演变中起主要作用。然而，研究HFpEF的性别差异是有限的。在本研究中，我们的目的是描述一个特征良好的HFpEF队列中的性别差异。对连续性HFpEF患者进行了有创血流动力学评估、心脏磁共振成像和运动试验。研究终点为：心源性死亡、HF住院或心源性死亡和全因死亡的联合终点。前瞻性入组了260例HFpEF患者。男性在运动能力方面受到的损害更大，并且患有的合并症也明显更多。男性有更明显的肺血管疾病，舒张压梯度更高，右心室射血分数更低。在随访期间，9.2%发生了心源性死亡，33.5%发生了联合终点死亡，17.3%发生了全因死亡。男性与心源性死亡独立相关，但与联合终点和全因死亡率均无关。我们在HFpEF患者中发现了明显的性别差异。心源性死亡在男性中更常见，但不是全因死亡。虽然男性更容易发展为右心表型并死于HFpEF，但女性更容易死于HFpEF。
Heart failure with preserved ejection fraction (HFpEF) affects more women than men, suggesting gender to play a major role in disease evolution. However, studies investigating gender differences in HFpEF are limited. In the present study we aimed to describe gender differences in a well-characterized HFpEF cohort. Consecutive HFpEF patients underwent invasive hemodynamic assessment, cardiac magnetic resonance imaging and exercise testing. Study endpoints were: cardiac death, a combined endpoint of HF hospitalization or cardiac death and all-cause death. 260 HFpEF patients were prospectively enrolled. Men were more compromised with regard to exercise capacity and had significantly more co-morbidities. Men had more pronounced pulmonary vascular disease with higher diastolic pressure gradients and a lower right ventricular EF. During follow-up, 9.2% experienced cardiac death, 33.5% the combined endpoint and 17.3% all-cause death. Male gender was independently associated with cardiac death, but neither with the combined endpoint nor with all-cause mortality. We detected clear gender differences in HFpEF patients. Cardiac death was more common among men, but not all-cause death. While men are more prone to develop a right heart phenotype and die from HFpEF, women are more likely to die with HFpEF.
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影响因子：
39.3
作者：
Gonzalez-Lopez, Esther;Gallego-Delgado, Maria;Garcia-Pavia, Pablo
通讯作者：
Garcia-Pavia, Pablo
影响因子：
168.9
作者：
Yusuf, S;Pfeffer, MA;Östergren, J
通讯作者：
Östergren, J
影响因子：
3.5
作者：
Aschauer, Stefan;Zotter-Tufaro, Caroline;Bonderman, Diana
通讯作者：
Bonderman, Diana
影响因子：
37.8
作者：
Gillmore, Julian D.;Maurer, Mathew S.;Hawkins, Philip N.
通讯作者：
Hawkins, Philip N.
影响因子：
6.2
作者：
Lang, Roberto M.;Badano, Luigi P.;Voigt, Jens-Uwe
通讯作者：
Voigt, Jens-Uwe