The influence of FDBA and autogenous bone particles on regeneration of calvaria defects in the rabbit: A pilot study
The influence of FDBA and autogenous bone particles on regeneration of calvaria defects in the rabbit: A pilot study
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DOI：
10.1016/j.aanat.2011.06.003
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发表时间：
2011-01-01
影响因子：
2.2
通讯作者：
Engelke, Wilfried
中科院分区：
文献类型：
--
作者：
Borie, Eduardo;Fuentes, Ramon;Engelke, Wilfried
使用三种生物材料检查骨形成的组织学行为，包括 8 毫米兔颅骨缺损是否会表现为临界尺寸缺损。在六块兔子顶骨中制作四个直径为 8 毫米的环锯缺损。对照缺损仅用凝固物维持，其他缺损分别用自体骨、FDBA（冻干骨同种异体移植物）和自体骨与FDBA的混合物填充。 15至90天后，每隔两周处死动物，并处理提取的样品用于组织学评估。在 90 天的观察期间，所有对照缺陷均显示骨形成不完整。 FDBA和FDBA与自体骨混合物填充的缺损在60天后表现出比自体骨更高的再生程度；然而，唯一在 90 天时显示原始缺陷完全矿化的生物材料是 FDBA。总之，8 mm 缺损可被视为临界尺寸缺损，并且只有 FDBA 在 90 天时显示出成熟的板层骨。 (C) 2011 爱思唯尔有限公司。版权所有。
The histological behavior of bone formation using three biomaterials was examined including whether an 8 mm rabbit calvarial defect would behave as a critical size defect. Four trephine defects of 8 mm diameter in were created six rabbit parietal bones. A control defect was maintained only with coagulum and others were filled with autologous bone, FDBA (freeze dried bone allograft) and a mixture of autologous bone with FDBA, respectively. The animals were sacrificed after between 15 and 90 days at intervals of two weeks and the extracted samples were processed for histological evaluation. All control defects showed incomplete bone formation during 90 days of observation. The defects filled with FDBA and mixture of FDBA-autologous bone exhibited a higher regeneration degree than autologous bone after 60 days; however, the only biomaterial revealing complete mineralization of the original defect at 90 days was FDBA. In conclusion, 8 mm defects can be considered as critical size defects and only FDBA showed mature lamellar bone at 90 days. (C) 2011 Elsevier GmbH. All rights reserved.