A new evolutionary paradigm for the Parkinson disease gene DJ-1
A new evolutionary paradigm for the Parkinson disease gene DJ-1
复制标题
DOI：
10.1093/molbev/msl186
复制
发表时间：
2007-02-01
影响因子：
10.7
通讯作者：
Marin, Ignacio
中科院分区：
文献类型：
--
作者：
Lucas, J. Ignasi;Marin, Ignacio
DJ-1基因由于与家族性帕金森病有关而被广泛研究。DJ-1属于一个复杂的基因超家族，包括原核生物和真核生物的代表。我们确定，许多原核生物群，如变形菌，蓝藻，螺旋体，厚壁菌门，或梭菌，有基因，往往被错误地称为“Thij”，这是非常接近的DJ-1的亲戚，到了这一点，他们不能清楚地从真核生物DJ-1基因的序列的系统发育分析分离。此外，与以前的研究表明DJ-1基因是动物特异性的相反，我们发现DJ-1基因存在于6个主要真核生物群中的至少5个：后囊动物（动物和真菌），植物，chromalveolata，挖洞动物和变形虫。因此，我们的研究结果提供了强有力的证据DJ-1基因起源于真核生物的起源之前。有趣的是，我们发现一些真菌物种，其中包括模式酵母粟酒裂殖酵母，有DJ-1样基因，最有可能的动物基因。这一发现为分析这组基因的功能开辟了新的途径。
The DJ-1 gene is extensively studied because of its involvement in familial Parkinson disease. DJ-1 belongs to a complex superfamily of genes that includes both prokaryotic and eukaryotic representatives. We determine that many prokaryotic groups, such as proteobacteria, cyanobacteria, spirochaetes, firmicutes, or fusobacteria, have genes, often incorrectly called "Thij," that are very close relatives of DJ-1, to the point that they cannot be clearly separated from the eukaryotic DJ-1 genes by phylogenetic analyses of their sequences. In addition, and contrary to a previous study that suggested that DJ-1 genes were animal specific, we show that DJ-1 genes are found in at least 5 of the 6 main eukaryotic groups: opisthokonta (both animals and fungi), plantae, chromalveolata, excavata, and amoebozoa. Our results thus provide strong evidence for DJ-1 genes originating before the origin of eukaryotes. Interestingly, we found that some fungal species, among them the model yeast Schizosaccharomyces pombe, have DJ-1-like genes, most likely orthologous to the animal genes. This finding opens new ways for the analysis of the functions of this group of genes.