Myeloid heme oxygenase-1: a new therapeutic target in anti-inflammation.
Myeloid heme oxygenase-1: a new therapeutic target in anti-inflammation.
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DOI：
10.2741/4685
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发表时间：
2018-06
期刊：
影响因子：
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通讯作者：
Mingyi Zhao;Minghua Yang;Weitao Que;Lin Zhong;M. Fujino;Xiao‐Kang Li
中科院分区：
文献类型：
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作者：
Mingyi Zhao;Minghua Yang;Weitao Que;Lin Zhong;M. Fujino;Xiao‐Kang Li
越来越多的证据表明，造血系统中骨髓亚群之间的协调相互作用在支持免疫系统的正常功能和促进外源性或内源性损伤后的稳态恢复方面起着重要作用。血红素加氧酶-1（HO-1）是几十年前发现的一种微粒体酶，可将血红素代谢成胆绿素、游离铁和一氧化碳。这种酶反应产生生物材料，有助于主要的免疫调节作用。具体地，骨髓细胞中的HO-1表达已被普遍认为驱动有效的抗炎和免疫抑制反应。本文综述了骨髓HO-1介导的免疫调节表型的潜在机制，并讨论了骨髓特异性HO-1诱导作为抗炎治疗策略的潜在应用。
An increasing amount of evidence reveals that an orchestrated interplay between myeloid subpopulations in the hematopoietic system plays a significant role in supporting normal functions of the immune system and facilitating homeostatic restoration upon exogenous or endogenous insults. Heme oxygenase-1 (HO-1), a microsomal enzyme discovered decades ago, can metabolize pro-oxidant heme into biliverdin, free iron, and carbon monoxide. This enzymatic reaction produces biological materials, contributing to major immunomodulatory effects. Specifically, HO-1 expression in myeloid cells has been generally acknowledged to drive potent anti-inflammatory and immunosuppressive responses. In this review, the authors focused on elucidating the potential mechanisms underlying myeloid HO-mediated immunomodulation phenotypes, and discussed the potential application of myeloid-specific HO-1 induction as an anti-inflammation therapeutic strategy.