Reproducibility of carotid intima-media thickness measurements in young adults
Reproducibility of carotid intima-media thickness measurements in young adults
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DOI：
10.1148/radiol.2472070691
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发表时间：
2008-05-01
期刊：
影响因子：
19.7
通讯作者：
Gilsanz, Vicente
中科院分区：
文献类型：
--
作者：
Gonzalez, Jaime;Wood, John C.;Gilsanz, Vicente
目的：前瞻性地比较的再现性，颈动脉内膜中层厚度（CIMT）的测量，从右和左颈动脉在年轻人通过使用超声（US）图像采集的最大尺寸，最小尺寸，和心电图（ECG）触发的心脏endobletole.Materials和方法：这项研究是符合健康保险责任法案，并批准了机构审查委员会;所有参与者提供了知情同意书。病史，人体测量，血压（BP）值，从50名男性和50名女性，年龄18-25岁。颈总动脉的图像通过使用15 L 8-MHz超声换能器从三个独立的完整心动周期获得。在每个周期的图像上测量CIMT，描述最窄和最宽的血管直径，并在ECG的R波处测量CIMT。使用配对t检验分析右侧和左侧颈动脉的测量值;使用非配对t检验分析可能的性别差异。通过使用变异系数和组内相关性（ICC）来确定再现性。Pearson相关性和多元回归分析被用来比较CIMT，体重指数（BMI），和BP.Results：CIMT值分别为7.2%和7%以上的帧显示最宽的管腔直径和R波心电图触发帧，分别比那些最宽的直径。右侧颈动脉的CIMT测量值比左侧高2.2%-3.1%（P <0.001），并且与BMI（r = 0.40，P <0.001）和收缩压（r = 0.34，P <0.001）显著相关。ICC更强的评估时，获得在三个不同的心动周期（0.92-0.98），而不是在一个（0.79-0.91）。结论：在健康的年轻人，CIMT测量的重复性是最大的结合值时，从两个颈动脉和/或从最大和最小动脉直径。
Purpose:To prospectively compare the reproducibility of carotid intima-media thickness (CIMT) measurements obtained from the right and left carotid arteries in young adults by using ultrasonographic (US) images acquired at the maximum dimension, minimum dimension, and electrocardiographically (ECG)-triggered cardiac end diastole.Materials and Methods:This study was HIPAA compliant and approved by the institutional review board; all participants provided informed consent. Medical history, anthropometric measurements, and blood pressure (BP) values were obtained from 50 men and 50 women aged 18-25 years. Images of the common carotid arteries were acquired from three independent complete cardiac cycles by using a 15L8-MHz US transducer. CIMT was measured on the images of each cycle that depicted the narrowest and widest vessel diameters, and at the R wave of the ECG. Measurements from the right and left carotid arteries were analyzed by using paired t tests; possible sex differences, by using unpaired t tests. Reproducibility was determined by using coefficients of variation and intraclass correlations (ICCs). Pearson correlations and multiple regression analyses were used to compare CIMT, body mass index (BMI), and BP.Results:CIMT values were 7.2% and 7% greater in frames showing the narrowest lumen diameter and in R-wave ECG-triggered frames, respectively, than in those with the widest diameter. CIMT measurements were 2.2%-3.1% greater in the right carotid artery than in the left (P < .001) and were significantly related to BMI (r = 0.40, P < .001) and systolic BP (r = 0.34, P < .001). ICCs were stronger when assessments were obtained in three different cardiac cycles (0.92-0.98), rather than in one (0.79-0.91).Conclusion:In healthy young adults, reproducibility of CIMT measurements is greatest when combining values from both carotid arteries and/or from the maximal and minimal arterial diameters.