Cardiovascular effects of caffeine in men and women
Cardiovascular effects of caffeine in men and women
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DOI：
10.1016/j.amjcard.2003.12.057
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发表时间：
2004-04-15
影响因子：
2.8
通讯作者：
Whitsett, TL
中科院分区：
文献类型：
--
作者：
Hartley, TR;Lovallo, WR;Whitsett, TL
咖啡因会增加血压（BP）。在男性中，摄入咖啡因后的急性血压升高是由于血管阻力增加，而心输出量没有变化。咖啡因对血液动力学的影响尚未在女性中进行过研究。因此，在一项双盲试验中测量了血压和血液动力学对咖啡因的反应，比较了年龄匹配的男性和女性在休息和精神压力期间的反应。咖啡因（3.3 mg/kg，相当于2至3杯煮咖啡）或安慰剂分别给予女性（n = 21和21）和男性（n = 16和19）（平均年龄分别为29和27岁）。血压，心输出量和血管阻力在休息时，在一个紧张的公众演讲模拟，阅读，并恢复观察。咖啡因导致女性（分别为4.5和3.3 mm Hg）和男性（分别为4.1和3.8 mm Hg）的收缩压和舒张压升高几乎相同。服用咖啡因的男性与服用安慰剂的男性相比，在余下的治疗过程中，血管阻力出现了预期的升高（p <0.05）。
Caffeine increases blood pressure (BP). In men, acute BP elevations after caffeine intake are due to an increase in vascular resistance, with no change in cardiac output. The hemodynamic effects of caffeine have not been studied in women. Accordingly, BP and hemodynamic responses to caffeine were measured in a double-blind trial comparing age-matched men and women at rest and during mental stress. Caffeine (3.3 mg/kg, equivalent to 2 to 3 cups of brewed coffee) or placebo was given to separate groups of women (n = 21 and 21) and men (n = 16 and 19) (mean ages 29 and 27 years, respectively). BP, cardiac output, and vascular resistance were observed at rest, during a stressful public-speaking simulation, reading aloud, and recovery. Caffeine caused nearly identical systolic and diastolic BP elevations in women (4.5 and 3.3 mm Hg, respectively) and men (4.1 and 3.8 mm Hg, respectively). Men given caffeine versus placebo showed the expected elevation in vascular resistance throughout the remainder of the protocol (p