Prognostic significance of tumor angiogenesis, Ki 67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal carcinoma - A prospective study
Prognostic significance of tumor angiogenesis, Ki 67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal carcinoma - A prospective study
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DOI：
10.1002/hed.10307
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发表时间：
2003-10-01
影响因子：
2.9
通讯作者：
Chan, ATC
中科院分区：
文献类型：
--
作者：
Ma, BBT;Poon, TCW;Chan, ATC
背景本研究前瞻性地探讨了p53癌蛋白（p53）、Ki 67抗原（Ki 67）、肿瘤血管生成（MVD）、表皮生长因子受体（EGFR）和HER 2受体蛋白（HER 2）在中国人未分化鼻咽癌（NPC）中的表达与预后的关系。1995年10月至1997年7月，在香港威尔斯亲王医院招募了78名中国人。对原发性肿瘤进行治疗前免疫组化制备，并前瞻性收集临床数据，直至2000年10月30日。这些标志物与总生存期（OS）、无病生存期（DIFS）、疾病进展时间（TTP）和UICC分期相关。在单变量分析中，EGFR表达与较差的OS（p = .0001）、DFS（p = .01）、较短的TTP（p = .0001）和晚期T分期（p = .036）相关。在UICC III-IV期疾病患者亚组中，EGFR强表达与弱或中度表达相比，与OS较差（p = 0.04）和TTP较短相关。HER 2表达与晚期UICC分期相关。（p = .006）。p53表达的存在与DFS较差（p = .01）和TTP缩短趋势（p = .06）相关。Ki 67抗原及MVD与胃癌的发生无相关性。在多变量分析中，只有EGFR表达与较短的OS和TTP显著相关。EGFR在未分化NPC中的表达与不良临床结局相关。p53和HER 2表达的预后作用是提示性的，但在这项研究中并不一致。EGFR阳性染色的相对较高的患病率支持在这种疾病中使用分子靶向治疗。(C)2003 Wiley Periodicals，Inc.
Background. This study prospectively examines the prognostic role of p53 oncoprotein (p53), Ki67-antigen (Ki67), tumor angiogenesis (MVD), epidermal growth factor receptor (EGFR), and HER2 receptor protein (HER2) expression in Chinese with undifferentiated nasopharyngeal carcinoma (NPC).Methods. Seventy-eight Chinese were recruited from October 1995 to July 1997 at the Prince of Wales Hospital, Hong Kong. Pretreatment immunohistochemical preparations of the primary tumor were made, and clinical data were collected prospectively until October 30, 2000. The markers were correlated with overall survival (OS), disease-free survival (DIFS), time to progression (TTP), and UICC stage.Results. On univariate analysis, EGFR expression correlated with poorer OS (p = .0001), DFS (p = .01), shorter TTP (p = .0001), and advanced T stage (p = .036). Strong EGFR expression, when compared with weak or moderate, was associated with poorer OS (p = .04) and shorter TTP in a subgroup of patients with UICC stage III-IV disease. HER2 expression was associated with advanced UICC stage.(p = .006). The presence of p53 expression correlated with poorer DFS (p = .01) and a trend toward shorter TTP (p = .06). No correlation was found with Ki67-antigen or MVD. On multivariate analysis, only EGFR expression was significantly linked to shorter OS and TTP.Conclusions. EGFR expression in undifferentiated NPC is associated with a poor clinical outcome. A prognostic role of p53 and HER2 expression is suggestive but not consistently defined in this study. The relatively high prevalence of positive staining for EGFR supports the use of molecular targeted therapy in this disease. (C) 2003 Wiley Periodicals, Inc.