Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus
Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus
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DOI：
10.1016/s0896-6273(01)00191-x
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发表时间：
2001-01-01
期刊：
影响因子：
16.2
通讯作者：
Heinemann, SF
中科院分区：
文献类型：
--
作者：
Contractor, A;Swanson, G;Heinemann, SF
盐酸盐受体改变苔藓纤维轴突的兴奋性，并在海马苔藓纤维突触的长期增强（LTP）诱导中发挥作用。这些先前的研究主要依赖于使用选择性尚不清楚的化合物。在本报告中，我们研究了在海碱盐受体敲除小鼠中苔藓纤维突触传递的短期和长期促进。我们发现在缺乏GluR6的小鼠中，LTP减少，而没有GluR5，盐酸盐受体亚基。此外，GluR6基因敲除小鼠的短期突触促进功能受损，表明藻酸盐受体作为苔藓纤维末端的突触前自受体促进突触传递。这些数据表明含有GluR6亚基的盐酸盐受体是苔藓纤维突触强度的重要调节剂。
Kainate receptors alter the excitability of mossy fiber axons and have been reported to play a role in the induction of long-term potentiation (LTP) at mossy fiber synapses in the hippocampus. These previous studies have relied primarily on the use of compounds whose selectivity is unclear. In this report, we investigate short- and long-term facilitation of mossy fiber synaptic transmission in kainate receptor knockout mice. We find that LTP is reduced in mice lacking the GluR6, but not the GluR5, kainate receptor subunit. Additionally, short-term synaptic facilitation is impaired in GluR6 knockout mice, suggesting that kainate receptors act as presynaptic autoreceptors on mossy fiber terminals to facilitate synaptic transmission. These data demonstrate that kainate receptors containing the GluR6 subunit are important modulators of mossy fiber synaptic strength.