PharmGKB, an Integrated Resource of Pharmacogenomic Knowledge.
PharmGKB, an Integrated Resource of Pharmacogenomic Knowledge.
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DOI：
10.1002/cpz1.226
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Klein TE
中科院分区：
文献类型：
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作者：
Gong L;Whirl-Carrillo M;Klein TE
药物基因组学知识库（PharmGKB）是一个集成的在线知识资源，用于了解遗传变异如何导致药物反应的变化。我们的重点不仅包括对临床实施有用的药物基因组学信息（例如，药物给药指南和注释的药物标签），而且还有催化科学研究和药物发现的信息（例如，变体药物注释和以药物为中心的途径）。截至2021年4月，PharmGKB的注释内容涵盖715种药物、1761个基因、227种疾病、165个临床指南和784个药物标签。我们从9000多篇已发表的论文中手动整理数据，以生成PharmGKB的内容。最近，我们还实施了一个自动化的自然语言处理（NLP）工具，以扩大我们的药物基因组学文献的覆盖面。本文包含一个基本的协议，描述了如何浏览PharmGKB网站，以检索有关基因和遗传变异如何影响药物疗效和毒性的信息。它还包括一个关于如何使用PharmGKB来帮助解释药物基因组学变异基因型或代谢者表型结果的方案。PharmGKB可在www.example.com上免费获得。
The Pharmacogenomics Knowledgebase (PharmGKB) is an integrated online knowledge resource for the understanding of how genetic variation contributes to variation in drug response. Our focus includes not only pharmacogenomic information useful for clinical implementation (e.g., drug dosing guidelines and annotated drug labels), but also information to catalyze scientific research and drug discovery (e.g., variant-drug annotations and drug-centered pathways). As of April 2021, the annotated content of PharmGKB spans 715 drugs, 1761 genes, 227 diseases, 165 clinical guidelines, and 784 drug labels. We have manually curated data from more than 9000 published papers to generate the content of PharmGKB. Recently, we have also implemented an automated natural language processing (NLP) tool to broaden our coverage of the pharmacogenomic literature. This article contains a basic protocol describing how to navigate the PharmGKB website to retrieve information on how genes and genetic variations affect drug efficacy and toxicity. It also includes a protocol on how to use PharmGKB to facilitate interpretation of findings for a pharmacogenomic variant genotype or metabolizer phenotype. PharmGKB is freely available at http://www.pharmgkb.org.