Prevalence of Candida albicans and non-albicans on the tongue dorsa of elderly people living in a post-disaster area: a cross-sectional survey.
Prevalence of Candida albicans and non-albicans on the tongue dorsa of elderly people living in a post-disaster area: a cross-sectional survey.
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DOI：
10.1186/s12903-017-0342-0
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发表时间：
2017-02-01
期刊：
影响因子：
2.9
通讯作者：
Kobayashi S
中科院分区：
文献类型：
--
作者：
Sato T;Kishi M;Suda M;Sakata K;Shimoda H;Miura H;Ogawa A;Kobayashi S
念珠菌是口腔内正常的共生生物。然而，在免疫功能下降的人群中，它们会引起口腔粘膜和严重的全身感染，这在老年人中很常见。在灾后地区，由于年轻一代的外流，老年居民的数量迅速增加。因此，我们研究了白色念珠菌和非白色念珠菌的患病率与口腔和全身状况、生活方式、药物和生活条件的关系。本研究于2014年进行。本研究的参与者是2011年东日本大地震和海啸严重破坏的大槌镇的266名60岁及以上的社区居民。用拭子法从舌背采集口腔标本。在CHROMagar™培养基上孵育48小时后，通过菌落的形态和色素沉着来鉴定白色念珠菌和非白色念珠菌。进行口腔和全身健康检查，评估以下内容：剩余牙齿数量和牙周状况、口腔卫生、假牙使用情况、肥胖、高血压、高脂血症和高血糖症。调查问卷涉及生活方式、药物和生活条件。利用上述变量，确定了涉及定殖的相关因素和每种类型念珠菌的数量。白色念珠菌142例（53.4%），非白色念珠菌63例（23.7%）。多项logistic回归分析显示，白色念珠菌定植的显著因素是“蛀牙”和“离家搬迁”。与非白色念珠菌定植相关的因素有“80岁以上”、“剩余牙数”、“使用假牙”和“肥胖”。相反，这些参数都与携带者体内非白色念珠菌的数量无关，而白色念珠菌的数量与“牙齿数”和“高血压”有显著相关。白色念珠菌和非白色念珠菌定殖的患病率相关因素不同。此外，除口腔状况外，系统和生活条件也影响灾后地区老年人白色念珠菌和非白色念珠菌的流行。本文的在线版本（doi:10.1186/s12903-017-0342-0）包含补充材料，仅供授权用户使用。
Candida species are normal commensal organisms of the mouth. However, they can cause oral mucosal and severe systemic infections in persons with reduced immune function, which is common in the very elderly. In post-disaster areas, the number of elderly residents rapidly increases due to the outflow of younger generations. Hence, we examined the prevalence of Candida albicans and non-albicans in association with oral and systemic conditions, life style, medications, and living conditions. This study was performed in 2014. Participants of this study were 266 community dwellers aged 60 years or older in Otsuchi town, which was severely damaged by the Great East Japan Earthquake and Tsunami in 2011. Oral specimens were collected from tongue dorsa by swabbing. After 48 h incubation on CHROMagar™ medium, C. albicans and non-albicans were identified by the morphology and pigmentation of the colonies. Oral and systemic health check-ups were performed to assess the following: number of remaining teeth and periodontal status, oral hygiene, use of dentures, obesity, hypertension, hyperlipidemia, and hyperglycemia. A questionnaire addressed lifestyle, medications, and living conditions. Using the variables above, the relative factors involved in the colonization and the amounts of each type of Candida were determined. C. albicans and non-albicans were detected in 142 (53.4%) and 63 (23.7%) participants, respectively. Multinomial logistic regression analyses revealed that the significant factors of colonization by C. albicans were “having decayed teeth” and “relocation from home”. Factors related to non-albicans colonization were “age over 80 years”, “number of remaining teeth”, “use of dentures”, and “obesity”. On the contrary, none of the parameters were related to the amount of non-albicans in the carrier, and the amount of C. albicans was significantly associated with “number of teeth” and “hypertension”. Prevalence-related factors differed between C. albicans and non-albicans colonization. In addition, other than oral status, systemic and living conditions affected the prevalence of both C. albicans and non-albicans in elderly people living in a post-disaster area. The online version of this article (doi:10.1186/s12903-017-0342-0) contains supplementary material, which is available to authorized users.