Changes in regional cerebral blood flow following mood challenge in drug-free, remitted patients with polar depression
Changes in regional cerebral blood flow following mood challenge in drug-free, remitted patients with polar depression
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DOI：
10.1002/da.20242
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发表时间：
2007-01-01
影响因子：
7.4
通讯作者：
Carney, Colleen
中科院分区：
文献类型：
--
作者：
Gemar, Michael C.;Segal, Zindel V.;Carney, Colleen
对缓解期抑郁症患者情绪激发的研究已经能够描述与抑郁症复发脆弱性相关的特定大脑变化。由于这些研究中的患者也接受维持药物治疗，因此从观察到的变化中减去药物作用的能力降低。我们的研究解决了这个问题。采用[O-15]H2O正电子发射断层扫描（PET）评估了11例无药物治疗、缓解的单相抑郁症患者在激发悲伤情绪后局部脑血流量（rCBF）相对于基线状态的变化。参与者显示前额叶皮层的激活减少，类似于接受情绪挑战的缓解，药物治疗的患者，以及没有药物治疗的急性抑郁症患者。先前报告的缓解患者的额中位改变不太可能是维持药物治疗的结果，更可能是复发脆弱性的证据。
Studies of mood provocation in remitted patients with depression have enabled the description of specific brain changes relevant to depression relapse vulnerability. Because patients in these studies were also receiving maintenance pharmacotherapy, the ability to subtract out the drug effect from the changes observed is reduced. Our study addresses this concern. Changes in regional cerebral blood flow (rCBF) among 11 medication free, remitted patients with unipolar depression relative to baseline state were assessed with [O-15]H2O positron emission tomography (PET) following provocation of sadness. Participants showed decreased activation in prefrontal cortex similar to those reported for remitted, medicated patients undergoing mood challenge, as well as for acutely depressed patients who were medication free. Previously reported mediofrontal changes in remitted patients are unlikely to be a consequence of maintenance medication and more likely are evidence of relapse vulnerability.