Adherence to high activity antiretrovial therapy (HAART) in pediatric patients infected with HIV : Issues and interventions
Adherence to high activity antiretrovial therapy (HAART) in pediatric patients infected with HIV : Issues and interventions
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DOI：
10.1007/s12098-007-0028-8
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发表时间：
2007-01-01
影响因子：
4.3
通讯作者：
Shah, Chirag A.
中科院分区：
文献类型：
--
作者：
Shah, Chirag A.
事实证明，HAART可有效抑制人类免疫缺陷病毒（HIV）复制，降低与HIV相关的发病率和死亡率，改善感染HIV的成人和儿童的生活质量。然而，药物对不服用药物的患者不起作用，并且在HIV感染的管理中，现在已经确定，最佳地坚持HAART对于接受治疗的患者的成功结果至关重要。至少95%的坚持HAART是最佳的，研究表明，< 95 % adherence is associated with virologic failure rate of >50%。影响HAART依从性的重要因素，例如与方案相关的复杂性、与患者/家庭相关的问题以及与医疗保健提供系统相关的因素，使HAART的依从性具有挑战性。尽管在发达国家和发展中国家已经调查了许多改善依从性的干预措施，但这一领域的大部分工作都集中在成人的依从性上，儿童的数据有限。因此，为了促进HAART在儿科人群中的依从性和改善结局，有必要深入了解影响依从性的因素和可以改善儿童依从性的干预措施。
It has been proven that HAART is effective in suppressing human immunodeficiency virus (HIV) replication, decreasing morbidity and mortality associated with HIV and improving quality of life in adults as well as children infected with HIV. However, drugs don't work in patients who don't take them and in the management of HIV infection it is now well established that optimum adherence to HAART is critical to successful outcome of patients receiving therapy. At least 95% adherence to HAART is optimum and studies have shown that < 95 % adherence is associated with virologic failure rate of > 50 %. Important factors that influence adherence to HAART such as regimen related complexities, patient/family related issues and factors related to healthcare delivery system makes adherence to HAART challenging. Although numerous interventions to improve adherence have been investigated in developed as well as developing countries, majority of work in this area is focused on adherence in adults and data in children is limited. Therefore, in order to facilitate adherence and improve outcome of HAART in pediatric population, it is necessary to have a deep understanding of the factors influencing adherence and interventions that can improve adherence in children.