Immunostaining of galectin‐3 and CD44v6 using fine‐needle aspiration for distinguishing follicular carcinoma from adenoma
Immunostaining of galectin‐3 and CD44v6 using fine‐needle aspiration for distinguishing follicular carcinoma from adenoma
复制标题
使用细针穿刺对半乳糖凝集素-3 和 CD44v6 进行免疫染色以区分滤泡性癌和腺瘤
DOI：
10.1002/dc.20156
复制
发表时间：
2004
影响因子：
1.3
通讯作者：
S. Noguchi
中科院分区：
文献类型：
--
作者：
J. Maruta;H. Hashimoto;H. Yamashita;H. Yamashita;S. Noguchi
为评价凝集素- 3和CD44变体6 （CD44v6）免疫染色在甲状腺滤泡性肿瘤细针穿刺细胞学（FNAC）中的临床应用价值，对79例甲状腺滤泡性肿瘤细胞学标本（35例滤泡性癌和44例滤泡性腺瘤）进行了研究。在滤泡性癌中，凝集素- 3和CD44v6的阳性率分别为89%和74%，在滤泡性腺瘤中，凝集素- 3和CD44v6的阳性率分别为25%和30%。在滤泡癌中，凝集素- 3或CD44v6的表达与囊膜浸润、血管浸润、转移或肿瘤大小等特征无显著相关性。
To evaluate the clinical applicability of galectin‐3 and CD44 variant 6 (CD44v6) immunostaining in fine‐needle aspiration cytology (FNAC) of thyroid follicular tumors, 79 cytological specimens (35 follicular carcinomas and 44 follicular adenomas) were studied. The positive rates of galectin‐3 and CD44v6 were 89 and 74% in follicular carcinoma, respectively, and 25 and 30% in follicular adenoma, respectively. There were no significant correlations between the expression of galectin‐3 or CD44v6 in follicular carcinoma and characteristics such as capsular invasion, vascular invasion, metastasis, or tumor size.