Active and passive smoking and the occurrence of natural menopause
Active and passive smoking and the occurrence of natural menopause
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DOI：
10.1097/00001648-199911000-00021
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发表时间：
1999-11-01
期刊：
影响因子：
5.4
通讯作者：
Bohlig, M
中科院分区：
文献类型：
--
作者：
Cooper, GS;Sandler, DP;Bohlig, M
我们研究了543名妇女的吸烟与自然绝经的关系，这些妇女前瞻性地记录了她们20多岁的月经数据。98名绝经期吸烟妇女的平均绝经年龄比362名从不吸烟妇女的平均绝经年龄小0.8岁（95%CL =-1.5，-0.0）（RR 1.3，95%CI = 1.0-1.7）。我们没有观察到前吸烟者自然绝经年龄的降低，当前吸烟者的剂量反应，或在家中被动吸烟暴露的绝经年龄较低。这些结果表明，吸烟对卵巢衰老的影响仅限于绝经过渡期的主动吸烟。
We examined smoking in relation to natural menopause in 543 women who prospectively recorded menstrual data from their 20s. Mean age at natural menopause was 0.8 years younger (95% CL = -1.5, -0.0) in 98 women who smoked at menopause compared with 362 never-smokers (RR 1.3, 95% CI = 1.0-1.7). We did not observe a decrease in age at natural menopause in former smokers, a dose-response among current smokers, or a lower age at menopause with passive smoke exposure at home. These results suggest that the effect of smoking on ovarian senescence is limited to active smoking during the menopausal transition.