Immunological and clinical differences between juvenile and adult onset of systemic lupus erythematosus
Immunological and clinical differences between juvenile and adult onset of systemic lupus erythematosus
复制标题
DOI：
10.1191/096120399678847786
复制
发表时间：
1999-01-01
期刊：
影响因子：
2.6
通讯作者：
Lapointe, N
中科院分区：
文献类型：
--
作者：
Carreño, L;López-Longo, FJ;Lapointe, N
前言：儿童系统性红斑狼疮(SLE)的病程通常比成人严重，但在以往的研究中，有时也有许多混杂因素的报道。目的：分析SLE青少年起病和成人起病的免疫学和临床特点。用放射免疫法检测抗dsDNA抗体，用ELISA法、对流免疫电泳法和免疫印迹法检测抗nRNP、抗Sm、抗Ro/SS-A和抗La/SS-B抗体。
Introduction: Systemic lupus erythematosus (SLE) in children usually follows a more severe course than in adults, but sometimes in the previous studies reported there are many confounding factors.Objective: To analyse the immunological and clinical characteristics of SLE juvenile onset and SLE adult onset.Methods: We studied 179 patients with SLE, 49 patients were aged 6-18 yrs at onset of disease. Anti-dsDNA antibodies were detected by radioimmunoassay and antibodies to extractable nuclear antigens (ENA): anti-nRNP, anti-Sm, anti-Ro/SS-A and anti-La/SS-B antibodies by ELISA, counterimmuno-electrophoresis and immunoblotting.Results: Juvenile-onset SLE shows a higher frequency of cutaneous vasculitis (44.8% vs 27.6%; P