Effects of a virtual voice-based coach delivering problem-solving treatment on emotional distress and brain function: a pilot RCT in depression and anxiety.
Effects of a virtual voice-based coach delivering problem-solving treatment on emotional distress and brain function: a pilot RCT in depression and anxiety.
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DOI：
10.1038/s41398-023-02462-x
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发表时间：
2023-05-12
影响因子：
6.8
通讯作者：
Ma, Jun
中科院分区：
文献类型：
--
作者：
Kannampallil, Thomas;Ajilore, Olusola A.;Lv, Nan;Smyth, Joshua M.;Wittels, Nancy E.;Ronneberg, Corina R.;Kumar, Vikas;Xiao, Lan;Dosala, Susanth;Barve, Amruta;Zhang, Aifeng;Tan, Kevin C.;Cao, Kevin K.;Patel, Charmi R.;Gerber, Ben S.;Johnson, Jillian A.;Kringle, Emily A.;Ma, Jun
基于消费者的语音助手有能力提供基于证据的治疗，但其治疗潜力在很大程度上是未知的。在一项基于虚拟语音的教练Lumen提供解决问题治疗的试点试验中，患有轻度至中度抑郁和/或焦虑的成年人被随机分配到Lumen干预组（n = 42）或候补对照组（n = 21）。主要结果包括16周内情绪反应和认知控制的神经测量值以及医院焦虑和抑郁量表[HADS]症状评分的变化。参与者为37.8岁（SD = 12.4），68%为女性，25%为黑人，24%为拉丁裔，11%为亚洲人。干预组右侧dlPFC（认知控制感兴趣的神经区域）的激活减少，但对照组增加，效应大小符合有意义效应的预定阈值（Cohen d = 0.3）。观察到左侧dlPFC和双侧杏仁核激活变化的组间差异，但幅度较小（d = 0.2）。右侧dlPFC激活的变化也与干预中自我报告的解决问题能力和回避的变化有意义地相关（r ≥ 0.4）。与等待名单对照组相比，管腔干预还导致HADS抑郁、焦虑和总体心理困扰评分降低，具有中等效应量（Cohen d = 0.49、0.51和0.55）。这项试点试验显示了一种新的数字心理健康干预对使用神经成像和抑郁和焦虑症状的认知控制的有希望的影响，为未来的验证性研究提供了基础证据。
Consumer-based voice assistants have the ability to deliver evidence-based treatment, but their therapeutic potential is largely unknown. In a pilot trial of a virtual voice-based coach, Lumen, delivering problem-solving treatment, adults with mild-to-moderate depression and/or anxiety were randomized to the Lumen intervention (n = 42) or waitlist control (n = 21). The main outcomes included changes in neural measures of emotional reactivity and cognitive control, and Hospital Anxiety and Depression Scale [HADS] symptom scores over 16 weeks. Participants were 37.8 years (SD = 12.4), 68% women, 25% Black, 24% Latino, and 11% Asian. Activation of the right dlPFC (neural region of interest in cognitive control) decreased in the intervention group but increased in the control group, with an effect size meeting the prespecified threshold for a meaningful effect (Cohen’s d = 0.3). Between-group differences in the change in activation of the left dlPFC and bilateral amygdala were observed, but were of smaller magnitude (d = 0.2). Change in right dlPFC activation was also meaningfully associated (r ≥ 0.4) with changes in self-reported problem-solving ability and avoidance in the intervention. Lumen intervention also led to decreased HADS depression, anxiety, and overall psychological distress scores, with medium effect sizes (Cohen’s d = 0.49, 0.51, and 0.55, respectively), compared with the waitlist control group. This pilot trial showed promising effects of a novel digital mental health intervention on cognitive control using neuroimaging and depression and anxiety symptoms, providing foundational evidence for a future confirmatory study.
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影响因子：
11.1
作者：
Goldstein-Piekarski AN;Wielgosz J;Xiao L;Stetz P;Correa CG;Chang SE;Lv N;Rosas LG;Lavori PW;Snowden MB;Venditti EM;Simmons JM;Smyth JM;Suppes T;Lewis MA;Ajilore O;Ma J;Williams LM
通讯作者：
Williams LM
影响因子：
2.2
作者：
Kannampallil, Thomas;Ronneberg, Corina R.;Wittels, Nancy E.;Kumar, Vikas;Lv, Nan;Smyth, Joshua M.;Gerber, Ben S.;Kringle, Emily A.;Johnson, Jillian A.;Yu, Philip;Steinman, Lesley E.;Ajilore, Olu A.;Ma, Jun
通讯作者：
Ma, Jun
DOI：
10.1016/j.lana.2021.100091
发表时间：
2022-01
期刊：
Lancet regional health. Americas
影响因子：
--
作者：
Ettman CK;Cohen GH;Abdalla SM;Sampson L;Trinquart L;Castrucci BC;Bork RH;Clark MA;Wilson I;Vivier PM;Galea S
通讯作者：
Galea S
影响因子：
12.8
作者：
Bell, Alissa C.;D'Zurilla, Thomas J.
通讯作者：
D'Zurilla, Thomas J.
影响因子：
120.7
作者：
Ma, Jun;Rosas, Lisa Goldman;Lavori, Philip W.
通讯作者：
Lavori, Philip W.