POSTNATAL-DEVELOPMENT OF CEREBELLAR CORTEX IN RAT .3. MATURATION OF COMPONENTS OF GRANULAR LAYER
POSTNATAL-DEVELOPMENT OF CEREBELLAR CORTEX IN RAT .3. MATURATION OF COMPONENTS OF GRANULAR LAYER
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DOI：
10.1002/cne.901450403
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发表时间：
1972-01-01
影响因子：
2.5
通讯作者：
ALTMAN, J
中科院分区：
文献类型：
--
作者：
ALTMAN, J
用组织学、组织化学、放射自显影和电镜技术研究了0、3、5、7、10、12、15、21和30日龄大鼠小脑皮质颗粒细胞的迁移和颗粒层各种成分的成熟。大部分颗粒细胞在第二周形成，但由于它们的迁移所需的时间和树突形成的滞后，在第三周开始之前，很少有肾小球突触与苔藓纤维形成，并且该过程在30天仍在进行中，在外部生发层溶解之后很久。高尔基体细胞的成熟是一个漫长的过程。当肾小球开始成熟时，它们的轴突与颗粒细胞树突形成突触。苔藓纤维与高尔基体树突形成突触。在第二周结束时，Lugaro细胞形成，在第三周期间，突触出现在它们的胞体上。在这些突触中，浦肯野细胞轴突的复发侧支被确定。Lugaro细胞可能是这些侧枝形成的神经节下丛和神经节上丛的主要靶点。总之，我们认为小脑皮质的神经发生主要经历了形态发生、突触发生和胶质发生三个阶段。然而，在大的浦肯野细胞中，一个区域（索马）的突触成熟可能在整个细胞（树突）的形态发生和突触发生成熟完成之前开始。
The migration of granule cells and the maturation of the various elements of the granular layer were studied in the cerebellar cortex of rats aged 0, 3, 5, 7, 10, 12, 15, 21 and 30 days with histological, histochemical, autoradiographic and electron microscopic techniques. The bulk of the granule cells are formed during the second week, but due to the time required for their migration and the lag in the formation of dendrites, few glomerular synapses are formed with mossy fibers before the beginning of the third week and the process is still in progress at 30 days, long after the dissolution of the external germinal layer. The maturation of Golgi cells is a protracted process. Their axons synapse with granule cell dendrites as soon as the glomeruli begin to mature. Evidence was obtained that mossy fibers synapse with the dendrites of Golgi cells. Towards the end of the second week the Lugaro cells are formed and synapses appear on their somata during the third week. Among these synapses the recurrent collaterals of Purkinje cell axons were identified. The Lugaro cells may be the primary targets of the infra and supraganglionic plexuses formed by these collaterals. In conclusion it was suggested that there are three major, successive stages in the neurogenesis of the cerebellar cortex, the morphogenic, synaptogenic and gliogenic. However, in the large Purkinje cell the synaptic maturation of one region (the soma) may begin before the morphogenic and synaptogenic maturation of the entire cell (the dendrites) is completed.