Prospective follow-up of 2,065 young unscreened women to study human papillomavirus incidence and clearance
Prospective follow-up of 2,065 young unscreened women to study human papillomavirus incidence and clearance
复制标题
DOI：
10.1002/ijc.27986
复制
发表时间：
2013-07-01
影响因子：
6.4
通讯作者：
Bekkers, R. L. M.
中科院分区：
文献类型：
--
作者：
Schmeink, C. E.;Massuger, L. F. A. G.;Bekkers, R. L. M.
人乳头瘤病毒（HPV）是宫颈上皮内瘤变和宫颈癌发生的必要因素。然而，HPV也是一种非常常见的性传播病毒，许多女性可以清除感染。为了研究HPV的发病率和清除率，对2,065名年龄在1829岁的妇女进行了为期12个月的随访，并要求她们每3个月提供一次自我收集的宫颈阴道样本并填写一份问卷。对于HPV DNA检测，使用SPF 10-DEIA LiPA 25系统。任何类型的高危型HPV和低危型HPV的发病率分别为17.0/1000人月和14.3/1000人月。HPV 16、52、51和31型具有最高的类型特异性发病率。HPV的发病率在单身和有新关系的女性中增加。终生性伴侣的数量越多，过去3个月内性接触的频率越高，HPV发病率越高。新发现的型别特异性高危型HPV感染和低危型HPV感染的总体清除率分别为61.2%和69.0%。与单身相比，有性关系和较高的性年龄都对任何类型的高危HPV的清除产生积极影响。在感染HPV 16的女性中，合并感染的女性HPV 16的清除率较低。总之，在荷兰年轻的研究人群中，HPV发病率与年龄无关，与其他西方国家相当。清除率仅与过去或当前性行为相关因素独立相关。
Human papillomavirus (HPV) is a necessary factor in the development of cervical intraepithelial neoplasia and cervical cancer. However, HPV is also a very common sexually transmitted virus and many women clear their infection. To study HPV incidence and clearance, 2,065 women, aged 1829 years, were followed for 12 months and were asked to provide a self-collected cervico-vaginal sample and fill-out a questionnaire every 3 months. For HPV DNA detection, the SPF10-DEIA LiPA25 system was used. Incidence rates of any-type high-risk HPV and low-risk HPV were 17.0 per 1,000-person months, and 14.3 per 1,000-person months, respectively. HPV types 16, 52, 51 and 31 had the highest type-specific incidence rates. HPV incidence was increased in singles, and women having a new relationship. A higher number of lifetime sex partners, and a higher frequency of sexual contacts in the past 3 months was associated with an increased HPV incidence. The overall clearance of the newly detected type-specific high-risk HPV infections and low-risk HPV infections was 61.2% and 69.0%, respectively. Having a sexual relationship compared to being single, and a higher sexual age both positively influenced the clearance of any-type high-risk HPV. Among the women infected with HPV 16, the women who had a co-infection had a lower proportion of clearance of HPV 16. In conclusion, in this young Dutch study population, HPV incidence rates are not related to age and comparable to other western countries. Clearance was only independently related to factors associated with sexual behavior, either past or current.