The role of MRSA in healthcare-associated pneumonia.
The role of MRSA in healthcare-associated pneumonia.
复制标题
MRSA 在医疗保健相关肺炎中的作用。
DOI：
10.1055/s-0028-1119809
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发表时间：
2009
影响因子：
3.2
通讯作者：
Wunderink,RichardG
中科院分区：
文献类型：
--
作者：
Lam,AnnaP;Wunderink,RichardG
医疗相关感染（包括医疗相关肺炎 (HCAP)）的一个重要的持续趋势是耐甲氧西林金黄色葡萄球菌 (MRSA) 的增加。社区获得性 MRSA 菌株的出现使管理变得更加复杂。我们回顾了 MRSA HCAP 的可能危险因素，其中包括既往抗生素治疗、鼻腔定植、不良的感染控制措施和既往病毒感染。还描述了抗生素耐药性的多种机制，并讨论了可能影响抗生素选择的毒力因素。回顾了万古霉素的局限性和利奈唑胺优越结果的证据。提到了社区获得性菌株的替代方案和未来的选择。
An important continued trend in healthcare-associated infection, including healthcare-associated pneumonia (HCAP), is the rise of methicillin-resistant Staphylococcus aureus (MRSA). The emergence of community-acquired strains of MRSA has complicated the management further. We review likely risk factors for MRSA HCAP, which include prior antibiotic therapy, nasal colonization, poor infection control practices, and antecedent viral infection. The multiple mechanisms of antibiotic resistance are also described, and virulence factors that may affect antibiotic choices are discussed. The limitations of vancomycin and evidence for superior outcomes with linezolid are reviewed. Alternatives for community-acquired strains and future options are mentioned.