The design of nanoparticles obtained by solvent evaporation: A comprehensive study
The design of nanoparticles obtained by solvent evaporation: A comprehensive study
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DOI：
10.1021/la034999q
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发表时间：
2003-10-28
期刊：
影响因子：
3.9
通讯作者：
Couvreur, P
中科院分区：
文献类型：
--
作者：
Desgouilles, S;Vauthier, C;Couvreur, P
乳液溶剂蒸发法制备纳米颗粒是一种非常流行的方法。本研究的目的是阐明在乳液溶剂蒸发过程中乙基纤维素（EC）和聚乳酸（PLA）纳米颗粒的形成机理。本研究主要基于溶剂蒸发过程中乳液和纳米颗粒表面电荷和尺寸的变化。根据所获得的数据和所使用的聚合物（EC或PLA），提出了两种不同的模型来解释纳米颗粒的形成。在EC模型中，由于溶剂蒸发的直接后果，乳状液滴收缩后，在形成稳定的无溶剂纳米颗粒之前发生聚结。相反，在聚乳酸模型中，没有或有限的聚结现象发生，因此，一个聚乳酸纳米颗粒是由一个（或只有几个）聚乳酸乳状液滴收缩后形成的。
The preparation of nanoparticles by emulsion solvent evaporation is a very popular method. The purpose of the present study was to clarify the mechanism by which nanoparticles of ethylcellulose (EC) and poly(lactic acid) (PLA) are formed during the emulsion solvent evaporation procedure. This study was mainly based on the measure of the variation of the emulsion and nanoparticle surface charge and size during the solvent evaporation process. From the data obtained and depending on the polymer used (EC or PLA), two different models are proposed to explain the nanoparticle formation. In the EC model, after shrinkage of the emulsion droplets as the direct consequence of solvent evaporation coalescence occurred before stable and solvent-free nanoparticles were formed. On the contrary, in the PLA model, no or limited coalescence was found to occur so that the picture is that one PLA nanoparticle originated from one (or only a few) PLA emulsion droplet after its shrinkage.