Model-based approach for analyzing prevalence of nuclear cataracts in elderly residents
Model-based approach for analyzing prevalence of nuclear cataracts in elderly residents
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DOI：
10.1016/j.compbiomed.2020.104009
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发表时间：
2020-11-01
影响因子：
7.7
通讯作者：
Sasaki, Hiroshi
中科院分区：
文献类型：
--
作者：
Kodera, Sachiko;Hirata, Akimasa;Sasaki, Hiroshi
最近的流行病学研究假设皮质性白内障的流行与紫外线辐射密切相关。然而，热带地区老年人的核性白内障患病率高于温带地区。导致核性白内障的主导因素一直存在广泛的争论。在这项研究中，热带和温带地区50-60岁的受试者因暴露在环境条件下而导致的晶状体温度升高被计算量化，这说明了体温调节的差异。体温调节反应模型被扩展到考虑热带地区的老年人。计算了亚洲五个城市不同天气条件下镜头温度的时间历程。晶状体中后部温度较高，与核性白内障的位置一致。尽管每天的最高温度是相似的，但镜片中的高温持续时间各不相同。核性白内障的患病率与计算的晶状体累积热剂量之间有很强的相关性(调整后的R2>；0.85)。我们建议使用累积热剂量来评估核性白内障的患病率。根据天气数据计算的一种新的衡量标准--湿球累计温度，将对不同城市的实际评估有用。
Recent epidemiological studies have hypothesized that the prevalence of cortical cataracts is closely related to ultraviolet radiation. However, the prevalence of nuclear cataracts is higher in elderly people in tropical areas than in temperate areas. The dominant factors inducing nuclear cataracts have been widely debated. In this study, the temperature increase in the lens due to exposure to ambient conditions was computationally quantified in subjects of 50-60 years of age in tropical and temperate areas, accounting for differences in thermoregulation. A thermoregulatory response model was extended to consider elderly people in tropical areas. The time course of lens temperature for different weather conditions in five cities in Asia was computed. The temperature was higher around the mid and posterior part of the lens, which coincides with the position of the nuclear cataract. The duration of higher temperatures in the lens varied, although the daily maximum temperatures were comparable. A strong correlation (adjusted R2 > 0.85) was observed between the prevalence of nuclear cataract and the computed cumulative thermal dose in the lens. We propose the use of a cumulative thermal dose to assess the prevalence of nuclear cataracts. Cumulative wet-bulb globe temperature, a new metric computed from weather data, would be useful for practical assessment in different cities.