High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population
High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population
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DOI：
10.1016/j.envres.2007.10.006
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发表时间：
2008-02-01
影响因子：
8.3
通讯作者：
Carpenter, David O.
中科院分区：
文献类型：
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作者：
Goncharov, Alexey;Haase, Richard F.;Carpenter, David O.
我们已经调查了总血清多氯联苯（PCBs）的浓度之间的关系，各种PCB同系物分组，和三种农药的总血清脂质在人类和没有自我报告的心血管疾病。从335名成年Akwesasne Mohawk人身上采集了血液样本，并分析了101种多氯联苯同系物、灭蚁灵、二氯二苯基二氯乙烯（DDE）和六氯苯（HCB）以及血清甘油三酯和胆固醇。采用结构方程模型，通过验证性因素分析定义潜在变量，分析血脂与多氯联苯和心脏病之间的关系。多氯联苯，血脂，年龄和体重指数（BMI）之间有显着的关联，这一事实证明了结构方程模型的应用。参与者的性别与任何其他研究变量无关。本研究的结果与一个模型一致，该模型将年龄视为多氯联苯获取的外生解释变量和生物驱动机制。此外，这项研究的结果与结论一致，即多氯联苯通过P450酶起作用，直接导致胆固醇和甘油三酯的合成增加，这些物质是已知的心血管疾病的主要风险因素。(c)2007年爱思唯尔公司All rights reserved.
We have investigated the relationships among the concentration of total serum polychlorinated biphenyls (PCBs), various PCB congener groupings, and three pesticides to total serum lipids in humans with and without self-reported cardiovascular disease. Blood samples were obtained from 335 adult Akwesasne Mohawks, and were analyzed for 101 PCB congeners, mirex, dichloro-diphenyl-dichloro-ethylene (DDE), and hexachloro benzene (HCB), as well as serum triglycerides and cholesterol. Structural equation modeling, following the definition of latent variables by means of confirmatory factor analysis, was used to analyze the relationships between serum lipids with PCBs and heart disease. There were significant associations among PCBs, lipids, age, and body mass index (BMI), a fact which justified the application of the structural equation model. Gender of the participant was unrelated to any of the remaining study variables. The results of this study are consistent with a model in which age is considered as both an exogenous explanatory variable and a biological driving mechanism for the acquisition of PCBs. Moreover, the results of this study are consistent with the conclusion that PCBs, acting through P450 enzymes, are directly responsible for increased synthesis of cholesterol and triglycerides, substances known to be major risk factors for cardiovascular disease. (c) 2007 Elsevier Inc. All rights reserved.