Reversible inhibition of human acetylcholinesterase by methoxypyridinium species.
Reversible inhibition of human acetylcholinesterase by methoxypyridinium species.
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DOI：
10.1016/j.bmcl.2013.09.008
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发表时间：
2013-11
影响因子：
2.7
通讯作者：
J. Topczewski;A. Lodge;S. N. Yasapala;Maurice K. Payne;Pedrom M Keshavarzi;D. Quinn
中科院分区：
文献类型：
--
作者：
J. Topczewski;A. Lodge;S. N. Yasapala;Maurice K. Payne;Pedrom M Keshavarzi;D. Quinn
有机磷化学战剂对乙酰胆碱酯酶（AChE）的不可逆抑制，需要使用解毒剂进行有效治疗。目前还没有解药能够在衰老发生后使乙酰胆碱酯酶复合体复活。本报告描述了超过30种新的乙酰胆碱酯酶抑制剂的亲和力，这些抑制剂可以作为衰老的乙酰胆碱酯- op加合物的复活剂。
The irreversible inhibition of acetylcholinesterase (AChE) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment. Currently no antidote is known that resurrects the phosphyl–AChE complex once aging has occurred. This report characterizes the affinities of over 30 new AChE inhibitors which could act as resurrecting agents for the aged AChE-OP adduct.