Local and Universal Action: The Paradoxes of Indole Signalling in Bacteria.
Local and Universal Action: The Paradoxes of Indole Signalling in Bacteria.
复制标题
DOI：
10.1016/j.tim.2020.02.007
复制
发表时间：
2020-07
影响因子：
15.9
通讯作者：
Ashraf Zarkan;Junyan Liu;M. Matuszewska;Hannah Gaimster;D. Summers
中科院分区：
文献类型：
--
作者：
Ashraf Zarkan;Junyan Liu;M. Matuszewska;Hannah Gaimster;D. Summers
吲哚是由许多细菌物种产生的信号分子，并且参与种内、种间和界间信号传导。尽管在这一领域发表的研究越来越多，吲哚信号的许多方面仍然是谜。关于吲哚的进出口机制存在分歧，也没有明确界定的目标，通过这些目标发挥其作用。吲哚研究文献的混乱和有时相互矛盾进一步阻碍了进展。我们探讨了这种缺乏一致性背后的原因，并推测是否发现了一种新的吲哚信号传导的脉冲模式，以及远离传统蛋白质靶点的想法，可能有助于克服这些问题，使该领域向前发展。
Indole is a signalling molecule produced by many bacterial species and involved in intraspecies, interspecies, and interkingdom signalling. Despite the increasing volume of research published in this area, many aspects of indole signalling remain enigmatic. There is disagreement over the mechanism of indole import and export and no clearly defined target through which its effects are exerted. Progress is hindered further by the confused and sometimes contradictory body of indole research literature. We explore the reasons behind this lack of consistency and speculate whether the discovery of a new, pulse mode of indole signalling, together with a move away from the idea of a conventional protein target, might help to overcome these problems and enable the field to move forward.