Survivin expression in intracranial ependymomas and its correlation with tumor cell proliferation and patient outcome
Survivin expression in intracranial ependymomas and its correlation with tumor cell proliferation and patient outcome
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DOI：
10.1309/pp25gaafkv82dtg
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发表时间：
2005-10-01
影响因子：
3.5
通讯作者：
Hainfellner, JA
中科院分区：
文献类型：
--
作者：
Preusser, M;Wolfsberger, S;Hainfellner, JA
Survivin expression has been described as a prognostic factor in various tumor types and has been shown to correlate with cytologic anaplasia in ependymoma. We immunohistochemically studied survivin expression and its association with Ki-67 and topoisomerase II alpha (TII alpha) expression and outcome in 63 patients with intracranial ependymoma. Survivin is expressed in a fraction of nuclei of tumor and endothelial cells including mitotic figures. Survivin indices range from 0.6% to 43.2% and correlate with Ki-67 and TII alpha indices. On average, 62.86% of Ki-67-expressing tumor cell nuclei coexpress survivin, whereas 92.2% of survivin-expressing nuclei coexpress Ki-67. High survivin, Ki-67, and TII alpha indices univariately correlated with an unfavorable outcome. In multivariate analysis, only the Ki-67 index remained an independent prognostic factor In ependymoma, survivin is expressed in a subset of prolifierating cells. High survivin expression is associated with poor patient outcome. However, the Ki-67 index is a more accurate prognostic marker than the survivin or TII alpha index.
