Skeletal malformations caused by the Dh (Dominant hemimelia) gene in mice.
Skeletal malformations caused by the Dh (Dominant hemimelia) gene in mice.
复制标题
由 Dh（显性半肢畸形）基因引起的小鼠骨骼畸形。
作者：
J. Suto;T. Wakayama;K. Imamura;S. Goto;K. Fukuta
对Dh基因引起的骨骼畸形进行了形态学表征。检查来自Dh/Dh、Dh/+和+/+基因型的新生小鼠和成年Dh/+小鼠的骨骼制备物。Dh基因在从胸部到尾部的轴向区域诱导骨骼畸形。肋骨与胸骨的连接有时不规则，胸骨的正常分割也被破坏。在某些病例中观察到肋骨腹侧部分的异常融合。腰椎数量少，形态异常。虽然这是罕见的，卷曲的尾巴也观察到由于扭曲的尾椎骨。
Morphological characterization of the skeletal malformations caused by the Dh gene was carried out. Skeletal preparations from newborn mice of Dh/Dh, Dh/+ and +/+ genotypes, and adult Dh/+ mice were examined. The Dh gene induced skeletal deformities at the axial regions from the thorax to the tail. Attachment of the ribs to the sternum was sometimes irregular, and normal segmentation of the sternum was also disrupted. Abnormal fusion of the ventral part of the rib was observed in some cases. Lumbar vertebrae were fewer in number and abnormal in shape. Although it was rare, a curled tail was also observed due to distortion of the caudal vertebrae.