An Immunohistochemical Approach to Lungfish Telencephalic Organization
An Immunohistochemical Approach to Lungfish Telencephalic Organization
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DOI：
10.1159/000229012
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发表时间：
2009-01-01
影响因子：
1.7
通讯作者：
Northcutt, R. Glenn
中科院分区：
文献类型：
--
作者：
Gonzalez, Agustin;Northcutt, R. Glenn
肺鱼的大脑在比较神经解剖学中很少受到关注，尽管这些鱼在系统发育中具有战略地位，因为它们目前被认为是四足动物最接近的现存亲戚。这种忽视可能是由于很难获得这些独特的动物，它们（与腔棘鱼一起）是现存的叶鳍鱼的唯一代表。先前的几项研究已经建立了肺鱼端脑的基本解剖结构，但主要端脑亚区域的内在组织的许多方面仍不清楚。参与大脑区域化的基因表达的多种神经递质、神经调节剂和转录因子的免疫组织化学定位有助于阐明肺鱼端脑组织的许多方面。在这里，我们描述了两种肺鱼（Protopterus dolloi 和 Neoceratodus forsteri）端脑的主要免疫组织化学特征。我们的分析强调了肺鱼和四足动物的共同特征。这些包括四个大脑皮层区域、基底神经节的不同纹状体和苍白球成分、隔膜的特定区域化以及三个杏仁核区域的存在。一般来说，免疫组织化学在肺鱼端脑研究中的应用表明，这种结构比以前想象的要复杂得多，并且它拥有两栖动物和羊膜动物中识别的所有主要亚区域。版权所有 (C) 2009 S. Karger AG，巴塞尔
The brains of lungfishes have received little attention in comparative neuroanatomy, in spite of the strategic position of these fishes in phylogeny, in that they are currently recognized as the closest living relatives of tetrapods. The neglect has probably been due to the difficulty of obtaining these unique animals, which comprise (along with the coelacanths) the only extant representatives of the lobe-finned fishes. Several previous studies have established the basic anatomy of the telencephalon in lungfishes, but many aspects of the intrinsic organization of the main telencephalic subregions have remained unclear. The immunohistochemical localization of diverse neurotransmitters, neuromodulators, and transcription factors expressed by genes involved in brain regionalization has served to clarify many aspects of the organization of the telencephalon in lungfishes. Here we describe the main immunohistochemical features of the telencephalon in two lungfish species, Protopterus dolloi and Neoceratodus forsteri. Our analysis highlights the common traits shared by lungfishes and tetrapods. These include four pallial regions, distinct striatal and pallidal components of the basal ganglia, specific regionalization of the septum, and the presence of three amygdaloid regions. In general, the use of immunohistochemistry in the study of the telencephalon of lungfishes reveals that this structure is notably more complex than previously thought and that it possesses all major subregions recognized in amphibians and amniotes. Copyright (C) 2009 S. Karger AG, Basel