Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues:: Effect of vanadate and fenugreek (Trigonella foenum graecum)
Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues:: Effect of vanadate and fenugreek (Trigonella foenum graecum)
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DOI：
10.1023/a:1016103131408
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发表时间：
2002-07-01
影响因子：
4.3
通讯作者：
Baquer, NZ
中科院分区：
文献类型：
--
作者：
Genet, S;Kale, RK;Baquer, NZ
在氧自由基可能是糖尿病严重程度和并发症的原因的前提下，检测了对照组、糖尿病组和治疗组大鼠组织中抗氧化酶过氧化氢酶（CAT）、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）的水平以及氧化损伤。糖尿病3周后，心脏CAT活性显著升高（约6倍），但肝脏CAT活性降低。SOD活性在肝脏中显著降低，而在脑中显著升高。肝脏GPx活性显著降低，肾脏GPx活性显著升高。观察到心脏和肾脏的氧化损伤显著增加，大脑的氧化损伤略有增加，肝脏和肌肉的氧化损伤减少。钒酸盐和胡芦巴（胡芦巴）管理糖尿病动物显示了逆转的干扰抗氧化水平和过氧化损伤。结果表明，氧化应激在糖尿病并发症中起着关键作用。钒酸盐和胡芦巴种子显示出令人鼓舞的抗氧化特性，并且可以是治疗糖尿病并发症逆转的有价值的候选者。
With the premise that oxygen free radicals may be responsible for the severity and complications of diabetes, the level of antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) as well as the oxidative damage were examined in the tissues of control, diabetic and treated rats. After 3 weeks of diabetes, the activity of CAT was significantly increased in heart in diabetes (about 6-fold) but decreased in liver. The SOD activity decreased significantly in liver but increased in brain. The activity of GPx decreased significantly in liver and increased in kidney. A significant increase was observed in oxidative damage in heart and kidney and a small increase in brain with decrease in liver and muscle. Vanadate and fenugreek (Trigonella foenum graecum) administration to diabetic animals showed a reversal of the disturbed antioxidant levels and peroxidative damage. Results suggest that oxidative stress play a key role in the complications of diabetes. Vanadate and fenugreek seeds showed an encouraging antioxidant property and can be valuable candidates in the treatment of the reversal of the complications of diabetes.