Inflammatory markers and depressed mood in older persons: Results from the Health, Aging and Body Composition study
Inflammatory markers and depressed mood in older persons: Results from the Health, Aging and Body Composition study
复制标题
DOI：
10.1016/s0006-3223(02)01811-5
复制
发表时间：
2003-09-01
影响因子：
10.6
通讯作者：
Pahor, M
中科院分区：
文献类型：
--
作者：
Penninx, BWJH;Kritchevsky, SB;Pahor, M
背景：重度抑郁症患者炎症细胞因子水平升高。我们在以社区为基础的老年人样本中研究了炎症标志物和抑郁情绪之间的联系。方法：数据来自参加健康、衰老和身体成分研究的3024名70-79岁功能良好的老年人。抑郁情绪被定义为流行病学研究中心抑郁量表得分为16分或更高。测定血浆白细胞介素(IL)-6、肿瘤坏死因子(TNF)- α、c反应蛋白（CRP）浓度。结果：与2879名非抑郁受试者相比，145名抑郁情绪患者的IL-6 （2.04 vs. 1.83 pg/mL, p= 0.02）、tnf - α (3.43 vs. 3.16 pg/mL, p= 0.05)和CRP （1.96 vs. 1.66 mg/L, p= 0.03）中位血浆水平较高。在对健康和人口变量进行调整后，抑郁情绪在至少两种炎症标志物的血浆水平较高（高于中位数）的人群中尤为普遍。与没有高水平的人相比，两种或所有三种标志物水平高的人抑郁情绪的风险分别为2.45（95%置信区间[CI]=1.34-4.47）和2.40 （95% CI=1.27-4.53）。抑郁情绪与血清IL-6水平的相关性在男性中明显强于女性。结论：在老年人中，抑郁情绪与高水平的炎症标志物相关，表明抑郁情绪是引起和/或由全身性炎症引起的。
Background: Patients with major depression have elevated levels of inflammatory cytokines. We examined the link between inflammatory markers and depressed mood in a community-based sample of older people.Methods: Data are from 3024 well-functioning older persons, 70-79 years of age, participating in the Health, Aging and Body Composition study. Depressed mood was defined as a Center for Epidemiologic Studies Depression scale score of 16 or higher. Plasma concentrations of interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, and C-reactive protein (CRP) were measured.Results: Compared with the 2879 nondepressed subjects, the 145 persons with depressed mood had higher median plasma levels of IL-6 (2.04 vs. 1.83 pg/mL, p=.02), TNF-alpha (3.43 vs. 3.16 pg/mL, p=.05), and CRP (1.96 vs. 1.66 mg/L, p=.03). After adjustment for health and demographic variables, depressed mood was especially prevalent among persons who had a high (above median) plasma level for at least two of the inflammatory markers. Compared with those without high levels, for persons with a high level for two or all three markers the risk of depressed mood was 2.45 (95% confidence interval [CI]=1.34-4.47) and 2.40 (95% CI=1.27-4.53), respectively. The association between depressed mood and serum level of IL-6 was significantly stronger in men than in women.Conclusions: In old age, depressed mood is associated with high levels of inflammatory markers, suggesting that depressed mood is causing and/or caused by systemic inflammation.