Serum Levels of Ficolin-3 (Hakata Antigen) in Patients with Systemic Lupus Erythematosus
Serum Levels of Ficolin-3 (Hakata Antigen) in Patients with Systemic Lupus Erythematosus
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DOI：
10.3899/jrheum.080361
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发表时间：
2009-04-01
影响因子：
3.9
通讯作者：
Jacobsen, Soren
中科院分区：
文献类型：
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作者：
Andersen, Trine;Munthe-Fog, Lea;Jacobsen, Soren
Objective. Ficolin-3是一种在自身免疫中具有重要作用的血清蛋白。本研究旨在探讨纤维胶凝蛋白-3（ficolin-3）在系统性红斑狼疮（SLE）患者及其临床亚型中的差异表达。采用酶联免疫吸附法（ELISA）测定95例SLE患者和103例健康对照者血清纤维胶凝蛋白-3（S-ficolin-3）水平。患者和对照组中S-纤维胶凝蛋白-3的中位数分别为56.1 μ g/ml（范围0至>= 87.3）和32.4 μ g/ml（10至>= 87.3）（p < 0.001）。纤维胶凝蛋白-3的增加与溶血、阳性Coombs试验和淋巴细胞减少相关，但与SLE疾病活动指数评分或C反应蛋白无关。在1例未检测到S-纤维胶凝蛋白-3的患者中，FCN 3基因显示正常。纤维胶凝蛋白-3的升高及其与SLE特异性临床表现的相关性可能提示纤维胶凝蛋白-3在SLE发病中的作用。（2009年2月1日首次发布; J Rheumol 2009; 36：757-9; doi：10.3899/jrheum.080361）
Objective. Ficolin-3 is a serum protein of putative importance in autoimmunity. Our objective was to investigate,my differential expression of ficolin-3 in patients with systemic lupus erythematosus (SLE) or its clinical subsets.Methods. Serum levels of ficolin-3 (S-ficolin-3) were determined in 95 patients with SLE and 103 healthy controls using an ELISA.Results. Median S-ficolin-3 was 56.1 mu g/ml (range 0 to >= 87.3) and 32.4 mu g/ml (10 to >= 87.3) in patients and controls, respectively (p < 0.001). Increased S-ficolin-3 was associated with hemolysis, Positive Coombs test, and lymphopenia, but not with SLE Disease Activity Index scores or C-reactive protein. In one patient without detectable S-ficolin-3, the FCN3 gene appeared normal.Conclusion. The elevation of S-ficolin-3 and its association with specific manifestations in SLE may indicate a pathogenetic role of ficolin-3 in SLE. (First Release Feb 1 2009; J Rheumatol 2009; 36:757-9; doi: 10.3899/jrheum.080361)