High blood pressure was associated with cognitive function in middle-age in the Whitehall II study
High blood pressure was associated with cognitive function in middle-age in the Whitehall II study
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DOI：
10.1016/j.jclinepi.2005.03.016
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发表时间：
2005-12-01
影响因子：
7.2
通讯作者：
Marmot, M
中科院分区：
文献类型：
--
作者：
Singh-Manoux, A;Marmot, M
背景和目标：研究表明，中年血压升高与老年认知能力受损有关。然而，目前尚不清楚这种关联是否适用于较年轻的年龄组。本研究的目的是检查中年男性和女性的高血压与一系列认知能力之间的关联。方法：数据来自 Whitehall 11 研究。在基线（1985-1988）和随后的两个数据收集阶段（1991-1994 和 1997-1999）获得血压测量值。当参与者 (N = 5,838) 年龄为 46-68 岁时，对认知功能（记忆测试、AH 4-I、Mill-Hill、语音和语义流畅性）进行评估（1997-1999）。 结果：结果显示舒张压和收缩压与认知表现之间存在微小的负相关，与年龄、教育程度、就业等级、吸烟状况、饮酒、使用抗高血压药物、诊断无关糖尿病和心血管疾病。前瞻性分析和横断面分析也发现了类似的关联。高血压对女性的影响更强，对评估执行功能的认知测量的影响更强。结论：本研究扩展了之前对老年参与者的研究，报告了高血压与中年男性和女性认知能力差之间存在微小但显着的关联。 (c) 2005 Elsevier Inc. 保留所有权利。
Background and Objectives: Research shows elevated levels of blood pressure in midlife to be linked to impaired cognitive performance in old age. However, it remains unclear if this association extends to younger age groups. The objective of this study was to examine the association between hypertension and a range of cognitive abilities in middle aged men and women.Methods: Data are from the Whitehall 11 study. Measures of blood pressure were obtained at baseline (1985-1988) and two subsequent phases of data collection (1991-1994 and 1997-1999). Cognitive function (memory test, AH 4-I, Mill-Hill, phonemic and semantic fluency) was assessed (1997-1999) when participants (N = 5,838) were aged 46-68 years old.Results: Results show a small inverse association between both diastolic and systolic blood pressure and cognitive performance, independent of age, education, employment grade, smoking status, alcohol consumption, use of antihypertensive medication, diagnoses of diabetes, and cardiovascular disease. Similar associations were seen with prospective and cross-sectional analyses. The effect of hypertension was stronger in women, and stronger for cognitive measures assessing executive function.Conclusion: Expanding on previous studies on older participants, the present study reports a small, but significant association between hypertension and poor cognitive performance in middle-aged men and women. (c) 2005 Elsevier Inc. All rights reserved.