Local field potentials in primate motor cortex encode grasp kinetic parameters.
Local field potentials in primate motor cortex encode grasp kinetic parameters.
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DOI：
10.1016/j.neuroimage.2015.04.008
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发表时间：
2015-07-01
期刊：
影响因子：
5.7
通讯作者：
Brochier T
中科院分区：
文献类型：
--
作者：
Milekovic T;Truccolo W;Grün S;Riehle A;Brochier T
到达和把握运动学是已知的编码在尖峰活动的神经元合奏和记录从灵长类动物运动皮层在运动规划和执行过程中的局部场电位（LFPs）。然而，鲜为人知的是，特别是在LFP，关于编码的动力学参数，如在相同的行动中施加在物体上的力。我们在两只猴子的运动皮质区MI和PMd植入了微电极阵列，以研究在计划和执行伸手抓取运动期间运动皮质LFP中抓取相关参数的编码。我们确定了在抓握过程中调制的LFP的三个分量，对应于低（0.3 - 7 Hz）、中（100 - 140 Hz）和高（180 - 250 Hz）频带。我们表明，所有这三个组成部分可以用来分类，不仅抓地力类型，但也在规划和执行过程中的抓取运动的对象负载。此外，我们证明，在规划或执行过程中记录的所有三个组件可以用来连续解码手指压力和手的位置相关的抓运动。低频分量和高频分量提供类似的分类和解码精度，其显著高于从中频分量获得的分类和解码精度。我们的研究结果表明，预期达到和把握动力学参数编码在多个LFP带在运动规划和执行。这些研究结果还表明，LFP是一个可靠的信号，用于控制与脑机接口中的对象负载和施加的压力相关的参数。
Reach and grasp kinematics are known to be encoded in the spiking activity of neuronal ensembles and in local field potentials (LFPs) recorded from primate motor cortex during movement planning and execution. However, little is known, especially in LFPs, about the encoding of kinetic parameters, such as forces exerted on the object during the same actions. We implanted two monkeys with microelectrode arrays in the motor cortical areas MI and PMd to investigate encoding of grasp-related parameters in motor cortical LFPs during planning and execution of reach-and-grasp movements. We identified three components of the LFP that modulated during grasps corresponding to low (0.3 - 7Hz), intermediate (∼10 - ∼40Hz) and high (∼80 - 250Hz) frequency bands. We show that all three components can be used to classify not only grip types but also object loads during planning and execution of a grasping movement. In addition, we demonstrate that all three components recorded during planning or execution can be used to continuously decode finger pressure forces and hand position related to the grasping movement. Low and high frequency components provide similar classification and decoding accuracies, which were substantially higher than those obtained from the intermediate frequency component. Our results demonstrate that intended reach and grasp kinetic parameters are encoded in multiple LFP bands during both movement planning and execution. These findings also suggest that the LFP is a reliable signal for the control of parameters related to object load and applied pressure forces in brain-machine interfaces.