The significance of extracellular calcium for the release of dopamine, acetylcholine and amino acids in conscious rats, evaluated by brain microdialysis
The significance of extracellular calcium for the release of dopamine, acetylcholine and amino acids in conscious rats, evaluated by brain microdialysis
复制标题
通过脑微透析评估细胞外钙对清醒大鼠多巴胺、乙酰胆碱和氨基酸释放的意义
DOI：
--
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
J. B. Vries
中科院分区：
文献类型：
--
作者：
B. Westerink;H. M. Hofsteede;G. Damsma;J. B. Vries
摘要研究了灌注液钙浓度对脑透析记录的纹状体多巴胺释放的影响。多巴胺的释放似乎对林格氏钙浓度非常敏感。接下来我们研究了三种已知的拮抗钙进入效应的不同方法是否能够影响多巴胺的释放。调查的条件是：使用无钙林格氏剂、输注镁和输注钙拮抗剂维拉帕米。在插管植入当天以及此后几天研究了钙拮抗作用。看来，镁输注是拮抗钙对多巴胺释放影响的最有效条件。镁输注对于预防药物诱发的电压依赖性多巴胺释放（由氟哌啶醇和 GBR 12909 共同给药诱导）也最有效。此外，镁输注似乎是乙酰胆碱释放的有效拮抗剂。相反，透析液中氨基酸的含量不受镁输注的影响。
SummaryThe influence of the calcium concentration of the perfusion fluid on the release of striatal dopamine recorded by brain dialysis was investigated. The release of dopamine appeared very sensitive to the calcium concentration of the Ringer. Next we studied whether three different methods known to antagonize the effects of calcium entry, were able to affect the release of dopamine. The conditions investigated were: the use of calcium-free Ringer, infusion of magnesium, and infusion of the calcium-antagonist verapamil. Calcium-antagonism was studied on the day of implantation of the cannula as well as on several days thereafter. It appeared that magnesium infusion was the most effective condition to antagonize the effects of calcium on the release of dopamine. Magnesium infusion was also most effective in preventing drug-evoked voltage-dependent dopamine release (induced by coadministration of haloperidol and GBR 12909). In addition magnesium infusion appeared a potent antagonist of acetylcholine release. In contrast, the dialysate content of aminoacids was not influenced by magnesium infusion.
血液和大脑中 pH 和 Ca2 的病理生理学。
影响因子：
2.1
作者：
Somjen,GG;Allen,BW;Balestrino,M;Aitken,PG
通讯作者：
Aitken,PG
影响因子：
56.9
作者：
MILLER, RJ
通讯作者：
MILLER, RJ