Proprioceptive feedback determines visuomotor gain in Drosophila
Proprioceptive feedback determines visuomotor gain in Drosophila
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DOI：
10.1098/rsos.150562
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发表时间：
2016-01-01
影响因子：
3.5
通讯作者：
Lehmann, Fritz-Olaf
中科院分区：
文献类型：
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作者：
Bartussek, Jan;Lehmann, Fritz-Olaf
多感觉整合是大多数动物有效运动控制的先决条件。特别是，昆虫令人印象深刻的空中表现依赖于快速和精确的集成，提供不同时间尺度上的反馈的多种感觉方式。在苍蝇，连续的视觉信号从复眼融合相位本体感受反馈，以确保精确的神经激活翼转向肌肉（WSM）内狭窄的时间相带的中风周期。这种相位锁定的激活依赖于分布在翅膀和陀螺笼头上的机械感受器。在这里，我们调查视觉转向性能的系留飞行果蝇减少笼头和翅膀反馈信号。使用飞行模拟器，我们评估视觉物体固定行为，optomotor高度控制和扫视逃避反射。行为分析显示，在飞行过程中，翅膀和笼头信号对视觉增益的拮抗作用。与对照组相比，抑制笼头反馈衰减，而抑制翅膀反馈增强动物的翅膀转向范围。我们的研究结果表明，运动指令的产生，由于视觉感知是动态控制的本体感觉。我们概述了一个潜在的生理机制的基础上的生物力学性能的WSM和感觉整合过程的运动神经元的水平。总的来说，这些发现有助于我们全面了解移动动物如何将感官信息与动态变化的时间结构相结合。
Multisensory integration is a prerequisite for effective locomotor control in most animals. Especially, the impressive aerial performance of insects relies on rapid and precise integration of multiple sensory modalities that provide feedback on different time scales. In flies, continuous visual signalling from the compound eyes is fused with phasic proprioceptive feedback to ensure precise neural activation of wing steering muscles (WSM) within narrow temporal phase bands of the stroke cycle. This phase-locked activation relies on mechanoreceptors distributed over wings and gyroscopic halteres. Here we investigate visual steering performance of tethered flying fruit flies with reduced haltere and wing feedback signalling. Using a flight simulator, we evaluated visual object fixation behaviour, optomotor altitude control and saccadic escape reflexes. The behavioural assays show an antagonistic effect of wing and haltere signalling on visuomotor gain during flight. Compared with controls, suppression of haltere feedback attenuates while suppression of wing feedback enhances the animal's wing steering range. Our results suggest that the generation of motor commands owing to visual perception is dynamically controlled by proprioception. We outline a potential physiological mechanism based on the biomechanical properties of WSM and sensory integration processes at the level of motoneurons. Collectively, the findings contribute to our general understanding how moving animals integrate sensory information with dynamically changing temporal structure.