A metathes is-based approach to the synthesis of 2-pyridones and pyridines
A metathes is-based approach to the synthesis of 2-pyridones and pyridines
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DOI：
10.1021/ol702684d
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发表时间：
2008-01-17
期刊：
影响因子：
5.2
通讯作者：
Procopiou, Panayiotis A.
中科院分区：
文献类型：
--
作者：
Donohoe, Timothy J.;Fishlock, Lisa P.;Procopiou, Panayiotis A.
闭环复分解反应已成功用于形成一系列二氢吡啶酮中间体，这些中间体处于正确的氧化态，可以进行碱诱导消除，从而揭示芳香族 2-吡啶酮。这种温和而新颖的六元杂芳族化合物方法可以以优异的总收率获得多种取代的吡啶。
The ring-closing metathesis reaction has been successfully employed to form a range of dihydropyridone intermediates, which are in the correct oxidation state to undergo a base-induced elimination to reveal the aromatic 2-pyridone. This mild and novel approach to six-membered heteroaromatic compounds then provides access to a wide variety of substituted pyridines in excellent overall yield.