Functional Differentiation of Memory Retrieval Network in Macaque Posterior Parietal Cortex
Functional Differentiation of Memory Retrieval Network in Macaque Posterior Parietal Cortex
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DOI：
10.1016/j.neuron.2012.12.019
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发表时间：
2013-02
期刊：
影响因子：
16.2
通讯作者：
Kentaro Miyamoto;Takahiro Osada;Yusuke Adachi;Teppei Matsui;H. M. Kimura;Y. Miyashita
中科院分区：
文献类型：
--
作者：
Kentaro Miyamoto;Takahiro Osada;Yusuke Adachi;Teppei Matsui;H. M. Kimura;Y. Miyashita
人类的功能磁共振成像研究表明，参与后顶叶皮层（PPC）在记忆检索。然而，猕猴PPC中相应的记忆相关区域尚未建立。在这个猴子的功能磁共振成像研究中，在正确识别以前看到的项目和拒绝看不见的项目的皮质活动的比较显示两个主要的PPC激活位点，其差异的特点是由一系列探针识别范式：PG/PGOP区顶下小叶，沿着与海马，是更积极的初始项目检索，而区域PEa/DIP顶内沟是最后一个项目。有效的连接分析显示，连接从海马PG/PGOP，但不PEa/DIP，增加在初始项目检索。两个顶叶区与差分串行探针识别配置文件被嵌入在两个不同的子网络的全脑检索相关的区域。这些功能的分离在猕猴PPC意味着检索相关的PPC网络在猕猴和人类的功能对应。
Human fMRI studies revealed involvement of the posterior parietal cortex (PPC) during memory retrieval. However, corresponding memory-related regions in macaque PPC have not been established. In this monkey fMRI study, comparisons of cortical activity during correct recognition of previously seen items and rejection of unseen items revealed two major PPC activation sites that were differentially characterized by a serial probe recognition paradigm: area PG/PGOp in inferior parietal lobule, along with the hippocampus, was more active for initial item retrieval, while area PEa/DIP in intraparietal sulcus was for the last item. Effective connectivity analyses revealed that connectivity from hippocampus to PG/PGOp, but not to PEa/DIP, increased during initial item retrieval. The two parietal areas with differential serial probe recognition profiles were embedded in two different subnetworks of the brain-wide retrieval-related regions. These functional dissociations in the macaque PPC imply the functional correspondence of retrieval-related PPC networks in macaques and humans.