Facile Access to Multi-Aryl 1H-Pyrrol-2(3H)-ones via Copper-TEMPO Mediated Cascade Annulation of Diarylethanones with Primary Amines and Mechanistic Insights
Facile Access to Multi-Aryl 1H-Pyrrol-2(3H)-ones via Copper-TEMPO Mediated Cascade Annulation of Diarylethanones with Primary Amines and Mechanistic Insights
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DOI：
10.1002/ejoc.201601178
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Aidong Zhang
中科院分区：
文献类型：
--
作者：
Xing Wang;Chen-Yang Zhang;Hai-Yang Tu;Aidong Zhang
A straightforward approach to an array of multi-aryl 1Hpyrrol-2(3H)-ones featuring an α-diarylated all-carbon quaternary center has been developed using diarylethanones and primary amines as the raw materials. A complete mechanism involving a CuO-TEMPO mediated multi-step cascade process with an inherent delicate balance of substituent electronic effect is depicted. Moreover, this class of multi-aryl β,γ-unsaturated γ-lactams demonstrates an intriguing aggregation-induced emission effect valuable for potential application in developing luminescent materials.
