Dietary fat differentially influences the lipids storage on the adipose tissue in metabolic syndrome patients
Dietary fat differentially influences the lipids storage on the adipose tissue in metabolic syndrome patients
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DOI：
10.1007/s00394-013-0570-2
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发表时间：
2014-03-01
影响因子：
5
通讯作者：
Lopez-Miranda, Jose
中科院分区：
文献类型：
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作者：
Camargo, Antonio;Meneses, Maria E.;Lopez-Miranda, Jose
脂肪组织现在被认为是一个高度活跃的代谢和内分泌器官。我们的目的是通过分析代谢综合征患者的脂肪组织基因表达来研究膳食脂肪对两种主要脂肪组织功能（内分泌和脂质储存）的影响。在LIPGENE研究中进行的一项随机对照试验将39名代谢综合征患者分配到4种等能饮食中的1种：（1）高饱和脂肪酸（HSFA），（2）高单不饱和脂肪酸（HMUFA），（3）低脂、高复合碳水化合物饮食，补充长链n-3脂肪酸（4）补充有安慰剂的低脂肪、高复合碳水化合物饮食（LFHCC），各持续12周。干预后进行反映脂肪酸组成的脂肪挑战，长期食用HSFA、LFHCC和LFHCC n-3饮食，而不是HMUFA饮食，降低了围脂蛋白空腹mRNA水平。LFHCC饮食消耗增加了空腹FABP 4表达，而LFHCC n-3饮食消耗降低了FABP 4表达。LFHCC餐降低，而LFHCC n-3餐增加餐后CAV 1表达，膳食脂肪的数量和质量诱导了不同的脂质储存和加工相关基因表达，这些基因可能通过共同的调控机制与脂肪因子的表达相互作用。
Adipose tissue is now recognized as a highly active metabolic and endocrine organ. Our aim was to investigate the effect of the dietary fat on the two main adipose tissue functions, endocrine and lipid store, by analyzing the adipose tissue gene expression from metabolic syndrome patients.A randomized, controlled trial conducted within the LIPGENE study assigned 39 metabolic syndrome patients to 1 of 4 isoenergetic diets: (1) high-saturated fatty acid (HSFA), (2) high-monounsaturated fatty acid (HMUFA), (3) low-fat, high-complex carbohydrate diet supplemented with long-chain n-3 fatty acids (LFHCC n-3), and (4) low-fat, high-complex carbohydrate diet supplemented with placebo (LFHCC), for 12 weeks each. A fat challenge reflecting the fatty acid composition as the original diets was conducted post-intervention.The long-term consumption of HSFA, LFHCC, and LFHCC n-3 diets, but not HMUFA diet, decreased the perilipin fasting mRNA levels. LFHCC diet consumption increased fasting FABP4 expression, while it was reduced by the consumption of LFHCC n-3 diet. LFHCC meal reduced, while LFHCC n-3 meal intake increased postprandial CAV1 expression.The quantity and quality of dietary fat induce differential lipid storage and processing related gene expression, which may interact with the expression of adipokines through common regulatory mechanisms.