BAR domains and membrane curvature: bringing your curves to the BAR
BAR domains and membrane curvature: bringing your curves to the BAR
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DOI：
10.1042/bss0720223
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
McMahon, HT
中科院分区：
文献类型：
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作者：
Gallop, JL;McMahon, HT
BAR（Bin、Amphiphysin和Rvs161/167）结构域是一类独特的二聚化结构域，其二聚化界面由一个膜结合表面环绕。在其二聚体形式下，膜结合界面是凹陷的，这使其能够更好地与弯曲的膜结合，即感知膜曲率。当以较高浓度存在时，该结构域能够稳定膜曲率，产生脂质小管。在多种蛋白质的许多情况下都能发现该结构域，其中该结构域的二聚化和膜结合功能可能对蛋白质活性产生深远影响。如果这些蛋白质如预期那样发挥作用，那么将会基于曲率产生膜亚结构域，从而在膜上存在额外的区室化层次。本文对BAR结构域的这些以及其他可能的功能进行了讨论。
BAR (bin, amphiphysin and Rvs161/167) domains are a unique class of dimerization domains, whose dimerization interface is edged by a membrane-binding surface. In its dimeric form, the membrane-binding interface is concave, and this gives the ability to bind better to curved membranes, i.e. to sense membrane curvature. When present at higher concentrations, the domain can stabilize membrane curvature, generating lipid tubules. This domain is found in many contexts in a wide variety of proteins, where the dimerization and membrane-binding function of this domain is likely to have a profound effect on protein activity. If these proteins function as predicted, then there will be membrane subdomains based on curvature, and thus there is an additional layer of compartmentalization on membranes. These and other possible functions of the BAR domain are discussed.