ORGANIZATION OF HRP-LABELED TRIGEMINAL MANDIBULAR PRIMARY AFFERENT NEURONS IN THE RAT
ORGANIZATION OF HRP-LABELED TRIGEMINAL MANDIBULAR PRIMARY AFFERENT NEURONS IN THE RAT
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DOI：
10.1002/cne.902150405
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发表时间：
1983-01-01
影响因子：
2.5
通讯作者：
RHOADES, RW
中科院分区：
文献类型：
--
作者：
JACQUIN, MF;SEMBA, K;RHOADES, RW
应用于三叉神经节横切下颌部分的辣根过氧化物酶（HRP）顺行转运至背侧和背内侧三叉神经脑干核复合体（TBNC）的初级传入终末区。神经节起源的初级 V 传入神经也在同侧小脑皮质（小腿 I 和 II，副絮球）和齿状、楔状、孤立、三叉上和背侧运动迷走核、小细胞网状结构、后区和 C[颈]1-C6 背角、I-V 层中可见。对侧尾核亚核和 C1-C2 背角也受到初级传入神经的支配，初级传入神经穿过脊髓灰质，终止于内侧，主要在 I、II 和 V 层。当 HRP 应用于下颌神经的各个感觉分支时，几乎所有这些投射也以各种组合进行标记：舌神经、下牙槽神经、下颌舌骨肌和耳颞神经。后 4 个病例中 HRP 的跨神经节转运揭示了神经节和 TBNC 4 个分支之间的分部内体细胞分布的有力证据。支配头部和面部后部和/或外侧部分（即耳颞和下颌舌骨）的细胞体在下颌背神经节区域中被发现的频率更高，而供应更多嘴口口周区域（即舌和下牙槽）的体体主要位于腹侧。下颌投影到 TBNC 的组成部分按地形组织在其所有 3 个维度的至少某些部分中。亚核偏好并不明确；所有 4 条神经至少支配主肌、口肌、极间肌和尾肌的某些部分，但下颌舌骨除外，它不投射到尾肌。舌纤维在主肌和口肌中最为突出，占据下颌骨投影到 TBNC 的内侧部分，并且仅下降到尾端头侧，最明显的是 I-III 层。除了远外侧边界外，下牙槽传入在 TBNC 和 C1-C2 的下颌部分中普遍存在。下颌舌骨末端稀疏，在极间最为突出，仅占据背外侧 TBNC 区域以及 C1-C3 的第 III 层和第 IV 层。下颌 TBNC 的耳颞神经支配在极间最重，并且主要局限于腹外侧区域。它的主要焦点是 C1-C4 的第三层和第四层。讨论了这种地形组织的临床意义，特别是关于尾肌和颈背角的头尾内分层。
Horseradish peroxidase (HRP) applied to the transected mandibular division of the trigeminal (V) ganglion was transported anterogradely to primary afferent terminal zones in the dorsal and dorsomedial trigeminal brainstem nuclear complex (TBNC). Primary V afferents of ganglionic origin were also visible in the ipsilateral cerebellar cortex (crus I and II, paraflocculus) and the dentate, cuneate, solitary, supratrigeminal and dorsal motor vagal nuclei, parvicellular reticular formation, area postrema and C[cervical]1-C6 dorsal horn, laminae I-V. Contralateral subnucleus caudalis and C1-C2 dorsal horn were also innervated by primary afferents which crossed in the spinal gray to terminate medially, primarily in laminae I, II and V. Almost all of these projections were also labeled in various combinations when HRP was applied to individual sensory branches of the mandibular nerve: lingual, inferior alveolar, mylohyoid and auriculotemporal. Transganglionic transport of HRP in the latter 4 cases revealed strong evidence for intradivisional somatotopy among the 4 branches in both the ganglion and TBNC. Cell bodies innervating posterior and/or lateral portions of the head and face (i.e., auriculotemporal and mylohyoid) were found with greater frequency in dorsal mandibular ganglion regions, while somata supplying more rostral oral-perioral regions (i.e., lingual and inferior alveolar) were predominant ventrally. Components of the mandibular projection to the TBNC were organized topographically in at least some portion of all of its 3 dimensions. Subnuclear preferences were not clear-cut; all 4 nerves innervated at least some portion of principalis, oralis, interpolaris and caudalis, save for mylohyoid, which did not project to caudalis. Lingual fibers were most prominent in principalis and oralis, occupied medial portions of the mandibular projection to the TBNC, and descended only to rostral caudalis, most notably laminae I-III. Inferior alveolar afferents were ubiquitous in the mandibular component of the TBNC and C1-C2, save for its far lateral border. Mylohyoid terminals were sparse, most prominent in interpolaris, and occupied only dorsolateral TBNC regions and laminae III and IV of C1-C3. The auriculotemporal innervation of the mandibular TBNC was heaviest in interpolaris and was restricted to mostly ventrolateral regions. Its primary focus was laminae III and IV of C1-C4. The clinical implications of this topographical organization are discussed, particularly with respect to the rostrocaudal intradivisional lamination in caudalis and the cervical dorsal horn.