Prospective study of cigarette smoking and amyotrophic lateral sclerosis
Prospective study of cigarette smoking and amyotrophic lateral sclerosis
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DOI：
10.1093/aje/kwh179
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发表时间：
2004-07-01
影响因子：
5
通讯作者：
Ascherio, A
中科院分区：
文献类型：
--
作者：
Weisskopf, MG;McCullough, ML;Ascherio, A
吸烟已被认为是肌萎缩侧索硬化症（ALS）的一个危险因素，但由于ALS的发病率低，这种关联仅用病例对照方法进行了研究。作者前瞻性地评估了美国癌症协会癌症预防研究II队列参与者中吸烟与ALS死亡率之间的关系，该队列于1982年招募了超过100万人，他们完成了生活方式问卷，包括基线时的详细吸烟史。死亡原因通过死亡证明确定; ALS直到1989年才单独确定。从1989年1月1日到1998年，有291名女性和330名男性死于ALS。目前吸烟者与从不吸烟者相比，女性ALS的相对风险为1.67（95%置信区间：1.24，2.24; p = 0.002），男性为0.69（95%置信区间：0.49，0.99; p = 0.04）。性别之间的相对风险估计差异具有统计学意义（p < 0.0003）。这项大型前瞻性研究提供了有限的证据，表明目前吸烟可能与女性ALS死亡率增加有关，但与男性无关。
Cigarette smoking has been proposed as a risk factor for amyotrophic lateral sclerosis (ALS), but because of the low incidence of ALS this association has been examined only with case-control methods. The authors prospectively assessed the relation between cigarette smoking and ALS mortality among participants in the Cancer Prevention Study II cohort of the American Cancer Society, a cohort of over 1 million people enrolled in 1982 who completed a lifestyle questionnaire including a detailed smoking history at baseline. Causes of deaths were ascertained through death certificates; ALS was not identified separately until 1989. From January 1, 1989, through 1998, 291 women and 330 men died from ALS. The relative risk of ALS among current smokers compared with never smokers was 1.67 (95% confidence interval: 1.24, 2.24; p = 0.002) in women and 0.69 (95% confidence interval: 0.49, 0.99; p = 0.04) in men. The difference in the relative risk estimates between the sexes was statistically significant (p < 0.0003). This large prospective study provides limited evidence that current cigarette smoking may be associated with increased death rates from ALS in women but not in men.