Multiple listing in lung transplant candidates: A cohort study
Multiple listing in lung transplant candidates: A cohort study
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DOI：
10.1111/ajt.15124
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发表时间：
2019-04-01
影响因子：
8.8
通讯作者：
Dhillon, Gundeep S.
中科院分区：
文献类型：
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作者：
Mooney, Joshua J.;Yang, Lingyao;Dhillon, Gundeep S.
肺移植候选者可以在多个移植中心列入候补名单，这种做法称为多重名单。与多重列名相关的因素以及多重列名是否会改变候补名单死亡率或肺移植的可能性尚不清楚。使用移植受者科学登记处的数据，将美国肺移植候补名单确定为单个或多个列表。比较了单个和多个列出的候选者的特征，并使用多变量逻辑回归来估计与多个列表的关联。使用精确匹配和倾向得分匹配方法的组合，将多个列出的候选人与单个列出的候选人进行匹配。使用 Cox 比例风险模型来估计多重列出与候补死亡率和接受移植之间的关系。 2.3% 的肺移植候补候选人出现了多重列入。年龄较小、女性、白种人、身材矮小、高抗体敏感性、大学或大学后教育、较低的肺分配评分和囊性纤维化诊断与多重列出独立相关。多重列入与肺移植可能性增加相关（调整后风险比 [aHR] 2.74，95% CI 2.37 至 3.16），但与候补死亡率无关（aHR 0.99，95% CI 0.68 至 1.44）。
Lung transplant candidates can be waitlisted at more than one transplant center, a practice known as multiple listing. The factors associated with multiple listing and whether multiple listing modifies waitlist mortality or likelihood of lung transplant is unknown. US lung transplant waitlist candidates were identified as either single or multiple listed using data from the Scientific Registry of Transplant Recipients. Characteristics of single and multiple listed candidates were compared and multivariable logistic regression was used to estimate associations with multiple listing. Multiple listed candidates were matched to single listed candidates using a combination of exact and propensity score matching methods. Cox proportional hazard models were used to estimate the relationship of multiple listing on waitlist mortality and receiving a transplant. Multiple listing occurred in 2.3% of lung transplant waitlist candidates. Younger age, female gender, white race, short stature, high antibody sensitization, college or postcollege education, lower lung allocation score, and a cystic fibrosis diagnosis were independently associated with multiple listing. Multiple listing was associated with an increased likelihood of lung transplant (adjusted hazard ratio [aHR] 2.74, 95% CI 2.37 to 3.16) but was not associated with waitlist mortality (aHR 0.99, 95% CI 0.68 to 1.44).