Circadian rhythm disruption is associated with an increased risk of sarcopenia: a nationwide population-based study in Korea
Circadian rhythm disruption is associated with an increased risk of sarcopenia: a nationwide population-based study in Korea
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DOI：
10.1038/s41598-019-48161-w
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发表时间：
2019-08-19
影响因子：
4.6
通讯作者：
Kim, Yoon Jae
中科院分区：
文献类型：
--
作者：
Choi, Youn I.;Park, Dong Kyun;Kim, Yoon Jae
睡眠质量下降会增加患骨质疏松症的风险。然而，像倒班工作一样，扰乱正常的昼夜节律对骨质疏松症风险的潜在影响尚未确定。分析了2008-2011年韩国国民健康和营养检查调查中9105名工人的数据。用双能X线骨密度仪测量的骨量减少，定义为年轻参照组的附件骨骼肌/体重指数平均值低于平均值一个标准差。与从未经历过倒班工作的小组相比，倒班工作组发生石棺减少的优势比(OR)为1.7(1.5-1.9)，可信区间为95%(95%CI)；即使在调整了混杂变量，包括年龄、性别、总脂肪质量、胰岛素抵抗状况、吸烟、饮酒、饮食和体力活动后，这种关联仍然存在。亚组分析结果显示，无规律倒班的工人发生骨质疏松症的风险最高(OR 1.8，95%CI 1.3~2.4)。倒班工作扰乱了昼夜节律，增加了骨质疏松症的风险。需要采取干预策略来预防轮班工人的石棺减少症。
Reduced sleep quality is associated with an increased risk of sarcopenia. However, the potential effects of disturbing the regular circadian rhythm, as occurs with shift work, on the risk of sarcopenia have not been established. Data from 9105 workers from the 2008-2011 Korean National Health and Nutrition Examination Survey were analyzed. Sarcopenia, measured by dual-energy X-ray absorptiometry, was defined as one standard deviation below the mean of the appendicular skeletal muscle/body mass index value of a young reference group. Compared to the group that had never experienced shift work, the odds ratio (OR) for sarcopenia with a 95% confidence interval (95% CI) for the shift work group was 1.7 (1.5-1.9); the association remained even after adjusting for confounding variables, including age, sex, total fat mass, insulin resistance profile, smoking, alcohol intake, diet, and physical activity. The results of the subgroup analysis indicated that the highest risk of sarcopenia was among workers engaging in shift work with an irregular schedule (OR 1.8, 95% CI 1.3-2.4). Disruption of circadian rhythm by shift work was associated with increased risk of sarcopenia. Intervention strategies are needed to prevent sarcopenia in shift workers.