Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
复制标题
血管内皮生长因子可以通过血小板衍生的生长因子受体发出信号。
DOI：
10.1083/jcb.200608093
复制
发表时间：
2007-05-07
影响因子：
7.8
通讯作者：
Kielty, Cay M
中科院分区：
文献类型：
--
作者：
Ball, Stephen G;Shuttleworth, C Adrian;Kielty, Cay M
血管内皮生长因子（VEGF-A）是血管细胞迁移和增殖的重要刺激因子。使用不表达VEGF受体的骨髓来源的人成体间充质干细胞（MSC），我们提供了VEGF-A可以刺激血小板源性生长因子受体（PDGFRs），从而调节MSC迁移和增殖的证据。VEGF-A与PDGFRα和PDGFRβ结合并诱导酪氨酸磷酸化，当抑制酪氨酸磷酸化时，导致VEGF-A诱导的MSC迁移和增殖减弱。该机制还显示可介导人真皮成纤维细胞（HDF）迁移。VEGF-A/PDGFR信号传导具有在组织再生和疾病期间调节血管细胞募集和增殖的潜力。
Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration and proliferation. Using bone marrow–derived human adult mesenchymal stem cells (MSCs) that did not express VEGF receptors, we provide evidence that VEGF-A can stimulate platelet-derived growth factor receptors (PDGFRs), thereby regulating MSC migration and proliferation. VEGF-A binds to both PDGFRα and PDGFRβ and induces tyrosine phosphorylation that, when inhibited, results in attenuation of VEGF-A–induced MSC migration and proliferation. This mechanism was also shown to mediate human dermal fibroblast (HDF) migration. VEGF-A/PDGFR signaling has the potential to regulate vascular cell recruitment and proliferation during tissue regeneration and disease.