Clinical significance of matrix metalloproteinase-7 expression in esophageal carcinoma.
Clinical significance of matrix metalloproteinase-7 expression in esophageal carcinoma.
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发表时间：
2000-03
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通讯作者：
K. Yamashita;M. Mori;T. Shiraishi;K. Shibuta;K. Sugimachi
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作者：
K. Yamashita;M. Mori;T. Shiraishi;K. Shibuta;K. Sugimachi
基质金属蛋白酶-7（MMP-7）是MMP家族的成员，具有广泛的底物谱。研究表明，它在肿瘤的侵袭和转移中起重要作用。然而，关于MMP-7在人食管癌中的临床意义的信息很少。因此，我们通过北方印迹分析研究了48个人食管肿瘤/正常对样品。结果显示：31例（65%）食管癌组织（T）中MMP-7 mRNA的表达高于相应的正常组织（N）。我们还统计学地评估了针对MMP-7阳性对照（用MMP-7基因转染的KYSE 150）校正的肿瘤MMP-7值（T值）。T值≥ 0.3者14例，淋巴结转移率高于T值≥ 0.3者34例，预后明显低于T值< 0.3者（P < 0.01）。多因素分析显示MMP-7表达状态是影响预后的独立因素（P = 0.0005）。研究结果表明，MMP-7可能是食管癌患者的一个新的预后因素。
Matrix metalloproteinase-7 (MMP-7) is a member of MMP family and has a wide variety of substrate spectra. It is reported to play an important role in carcinoma invasion and metastasis. There is, however, little information on the clinical significance of MMP-7 in human esophageal carcinoma. We thus studied 48 tumor/normal pair samples of human esophagus by Northern blot analysis. The results demonstrated that the tumor tissue (T) of esophageal carcinoma showed a higher expression of MMP-7 mRNA than the corresponding normal tissue (N) in 31 cases (65%). We also statistically evaluated tumor MMP-7 value (T value) corrected for MMP-7-positive control (KYSE150 transfected with the MMP-7 gene). Fourteen cases with T value > or = 0.3 showed a higher frequency of lymph node metastasis than 34 cases with T value or = 0.3 showed a significantly poorer prognosis than those with T value < 0.3 (P < 0.01). Multivariate analysis demonstrated that the MMP-7 expression status was the independent factor relating to the prognosis (P = 0.0005). The findings indicated that MMP-7 might be a novel prognostic factor for patients with esophageal carcinoma.