Olefin Difunctionalization for the Synthesis of Tetrahydroisoquinoline, Morpholine, Piperazine, and Azepane.
Olefin Difunctionalization for the Synthesis of Tetrahydroisoquinoline, Morpholine, Piperazine, and Azepane.
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DOI：
10.1021/acs.orglett.3c03690
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发表时间：
2024-01
期刊：
影响因子：
5.2
通讯作者：
Akanksha Chhikara;Navdeep Kaur;Ernest B Wolke;Emily A Boes;Alex M Nguyen;J. Ariyarathna;P. Baskaran;Chloe E Villa;Anthony H Pham;Victoria J Kremenets;Sydney R Kutcher;Jonathon T Truong;Wei Li
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文献类型：
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作者：
Akanksha Chhikara;Navdeep Kaur;Ernest B Wolke;Emily A Boes;Alex M Nguyen;J. Ariyarathna;P. Baskaran;Chloe E Villa;Anthony H Pham;Victoria J Kremenets;Sydney R Kutcher;Jonathon T Truong;Wei Li
该报告概述了合成多种 N-杂环的通用策略。通过利用常见的烯烃，这个简单的方案有利于它们与各种双功能试剂的偶联。此外，它可以与C-H胺化技术相结合，在多组分级联偶联过程中直接生产N-杂环。该过程中采用的独特的键断开逻辑强调了其通过级联耦合实现快速简化的效率。
This report outlines a versatile strategy for synthesizing a diverse array of N-heterocycles. By the utilization of common olefins, this simple protocol facilitates their coupling with various bifunctional reagents. Furthermore, it can be integrated with C-H amination techniques to directly produce N-heterocycles in a multicomponent cascade coupling process. The unique bond disconnection logic employed in this process underscores its efficiency in achieving rapid simplification through cascade couplings.