Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues
Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues
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DOI：
10.1016/j.bbrc.2005.05.002
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发表时间：
2005-07-01
影响因子：
3.1
通讯作者：
Miyashita, K
中科院分区：
文献类型：
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作者：
Maeda, H;Hosokawa, M;Miyashita, K
线粒体解偶联蛋白1（UCP1）通常仅在棕色脂肪组织（BAT）中表达，是代谢产热的关键分子，以避免过量的脂肪积累。然而，成年人体内几乎没有BAT。因此，UCP1在BAT以外的组织中的表达有望减少腹部脂肪。在这里，我们显示了减少腹部白色脂肪组织（WAT）的重量，在大鼠和小鼠喂养食用海藻，裙带菜脂质。在喂食裙带菜脂质的小鼠的WAT中检测到UCP1蛋白和mRNA的清晰信号，尽管在喂食对照饮食的小鼠的WAT中几乎没有UCP1的表达。裙带菜脂类主要由糖脂和海藻类胡萝卜素、岩藻黄素组成。在喂食岩藻黄质的小鼠中，WAT重量显著降低并且UCP 1在WAT中明确表达，而在喂食糖脂的小鼠中WAT重量没有差异并且UCP 1几乎没有表达。该结果表明，岩藻黄素上调WAT中UCP1的表达，这可能有助于降低WAT重量。(C)2005年爱思唯尔公司All rights reserved.
Mitochondrial uncoupling protein 1 (UCP1) is usually expressed only in brown adipose tissue (BAT) and a key molecule for metabolic thermogenesis to avoid an excess of fat accumulation. However, there is little BAT in adult humans. Therefore, UCP1 expression in tissues other than BAT is expected to reduce abdominal fat. Here, we show reduction of abdominal white adipose tissue (WAT) weights in rats and mice by feeding lipids from edible seaweed, Undaria pinnatifida. Clear signals of UCP1 protein and mRNA were detected in WAT of mice fed the Undaria lipids, although there is little expression of UCP1 in WAT of mice fed control diet. The Undaria lipids mainly consisted of glycolipids and seaweed carotenoid, fucoxanthin. In the fucoxanthin-fed mice, WAT weight significantly decreased and UCP1 was clearly expressed in the WAT, while there was no difference in WAT weight and little expression of UCP1 in the glycolipids-fed mice. This result indicates that fucoxanthin upregulates the expression of UCP1 in WAT, which may contribute to reducing WAT weight. (C) 2005 Elsevier Inc. All rights reserved.