Neuroimaging in tuberous sclerosis complex
Neuroimaging in tuberous sclerosis complex
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DOI：
10.1097/wco.0b013e3280895d93
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发表时间：
2007-04
影响因子：
4.8
通讯作者：
A. Luat;M. Makki;H. Chugani
中科院分区：
文献类型：
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作者：
A. Luat;M. Makki;H. Chugani
综述目的在这篇综述中，我们讨论了结节性硬化症（TSC）患者神经影像学的最新进展，强调其在改善临床管理方面的应用，特别是在顽固性癫痫的情况下。最近的发现结构和功能成像的进展导致了 TSC 脑损伤的进一步表征。新的磁共振成像技术已经开发出来，可以描绘结节性硬化症中大脑结构异常的程度。弥散张量成像揭示了脑部病变的微观结构异常以及 TSC 中形态正常的白质。它可以潜在地识别癫痫发生区。使用 2-脱氧-2-[18F]氟-D-葡萄糖进行正电子发射断层扫描可以评估 TSC 脑功能异常的全部程度。 α[11C]甲基-L-色氨酸正电子发射断层扫描已被证明是识别致癫痫块的有用工具，并改善了 TSC 癫痫手术的结果。摘要 TSC 神经影像学的重大进展已经显示出广泛的大脑结构和功能异常的证据。在患有顽固性癫痫的 TSC 患者中，新的神经影像学方法现在可以提供对癫痫发生区的准确评估，从而可以更好地识别癫痫手术后可以获得良好癫痫结果的患者。
Purpose of reviewIn this review we discuss recent advances in the neuroimaging of patients with tuberous sclerosis complex (TSC), highlighting its application in improving clinical management, particularly in the case of intractable epilepsy. Recent findingsProgress in structural and functional imaging has led to further characterization of the brain lesions in TSC. New magnetic resonance imaging techniques that can delineate the extent of structural brain abnormalities in TSC have been developed. Diffusion tensor imaging unveils the microstructural abnormalities of the brain lesions and of the morphologically normal appearing white matter in TSC. It can potentially identify the epileptogenic zone. Positron emission tomography scanning with 2-deoxy-2-[18F]fluoro-D-glucose can assess the full extent of functional brain abnormalities in TSC. The use of alpha [11C] methyl-L-tryptophan positron emission tomography scanning has proven to be a useful tool in the identification of epileptogenic tubers and has improved the outcome of surgery for epilepsy in TSC. SummaryMajor advances of neuroimaging in TSC have shown evidence of widespread structural and functional brain abnormalities. In TSC patients with intractable epilepsy, new neuroimaging modalities can now provide an accurate assessment of the epileptogenic zone, thereby permitting improved identification of patients who can have good seizure outcome following surgery for epilepsy.